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A Report of Zika Virus Seroprevalence in Republic of the Congo
- Source :
- Vector-Borne and Zoonotic Diseases, Vector-Borne and Zoonotic Diseases, Mary Ann Liebert, 2019, ⟨10.1089/vbz.2019.2466⟩, Vector-Borne and Zoonotic Diseases, Mary Ann Liebert, 2019, Epub ahead of print. ⟨10.1089/vbz.2019.2466⟩, Vector-Borne and Zoonotic Diseases, 2019, ⟨10.1089/vbz.2019.2466⟩
- Publication Year :
- 2020
- Publisher :
- Mary Ann Liebert Inc, 2020.
-
Abstract
- International audience; Zika virus (ZIKV) is an arthropod-borne RNA virus (arbovirus), belonging to the Spondweni serogroup. ZIKV was first described in Africa in 1947 and remained sporadic until Micronesia outbreak in 2007, which was followed by outbreaks in the Pacific Islands, Latin America, and the Caribbean. Subsequent to the epidemics, ZIKV revealed its severity as virus was sexually transmissible, and it was associated with serious fetal and neurological complications. ZIKV originated from Africa; however, little is known about the epidemiology of the virus in African populations. Following a recent study in Cameroon that evidenced low ZIKV epidemiology associated with a presumptive (peri-)sylvatic transmission, we performed a seroepidemiological study in Republic of the Congo, neighbor of Cameroon. To accomplish this, 386 serum specimens from volunteer blood donors collected in 2011 from rural and urban areas of Republic of the Congo were tested with ZIKV-specific methodology; primary screening with anti-NS1 ZIKV IgG ELISA followed by confirmation with cytopathic effect (CPE)-based virus neutralization test (VNT). ZIKV seropositivity was determined as low as 1.8%, varying slightly between urban and rural areas (1.7% and 3.6%). These results demonstrate that the majority of the population of Republic of the Congo is immunologically naïve against ZIKV with a presumptive (peri-)sylvatic transmission cycle, which emphasizes the importance of surveillance studies in Africa.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
[SDV]Life Sciences [q-bio]
030231 tropical medicine
Population
Blood Donors
Antibodies, Viral
Microbiology
Arbovirus
Virus
Zika virus
Young Adult
03 medical and health sciences
0302 clinical medicine
Seroepidemiologic Studies
Virology
Epidemiology
medicine
Humans
Seroprevalence
education
[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology
ComputingMilieux_MISCELLANEOUS
education.field_of_study
biology
Zika Virus Infection
Transmission (medicine)
Outbreak
030108 mycology & parasitology
biology.organism_classification
medicine.disease
3. Good health
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Infectious Diseases
Congo
History, 16th Century
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Africa
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
seroepidemiology
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- ISSN :
- 15577759 and 15303667
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Vector-Borne and Zoonotic Diseases
- Accession number :
- edsair.doi.dedup.....4d02c96d29cd5b5ac5f00cc6eaf8f254