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Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension
- Source :
- Frontiers in Medicine, Vol 7 (2020), Frontiers in Medicine
- Publication Year :
- 2020
- Publisher :
- Frontiers Media SA, 2020.
-
Abstract
- Background: Superoxide dismutases (SODs) are an important family of antioxidant enzymes that modulate reactive oxygen species levels. It is largely unknown which SOD isoform(s) change in vivo in idiopathic pulmonary arterial hypertension (IPAH) patients. Methods: A total of 133 consecutive adult IPAH patients who underwent bone morphogenetic protein receptor type 2 (BMPR2) genetic counseling were enrolled in this prospective study. The plasma activities of three subtypes of SOD [copper–zinc (Cu/Zn-SOD), manganese (Mn-SOD), and extracellular SOD (Ec-SOD)] were examined. Results: The activities of SODs were significantly lower in IPAH patients than in healthy subjects. However, only Ec-SOD activity in BMPR2 mutation patients was significantly decreased compared to those in patients without a mutation. The reduced Ec-SOD activity was markedly associated with mean pulmonary arterial pressure, pulmonary vascular resistance (PVR), and 6-min walking distance (6MWD). The reduction of Mn-SOD activity was only associated with 6MWD. There was no association between Cu/Zn-SOD and hemodynamics. Patients with a lower Ec-SOD level had a worse survival compared to those with a higher baseline. The reduced Ec-SOD activity and the raised PVR increased the mortality risk. Conclusions: Ec-SOD was correlated with BMPR2 mutation, hemodynamic dysfunction, and poor outcomes. Circulating Ec-SOD could be a potentially vital antioxidant enzyme in the pathogenesis of IPAH.
- Subjects :
- 0301 basic medicine
extracellular SOD
medicine.medical_specialty
Hemodynamics
030204 cardiovascular system & hematology
Superoxide dismutase
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Internal medicine
idiopathic pulmonary arterial hypertension
medicine
Extracellular
Prospective cohort study
Original Research
chemistry.chemical_classification
lcsh:R5-920
Reactive oxygen species
biology
business.industry
biomarkers
General Medicine
superoxide dismutases
BMPR2
030104 developmental biology
Endocrinology
medicine.anatomical_structure
chemistry
biology.protein
Vascular resistance
Medicine
prognosis
lcsh:Medicine (General)
business
Subjects
Details
- ISSN :
- 2296858X
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Frontiers in Medicine
- Accession number :
- edsair.doi.dedup.....4d1ce331a07930388a040204b65af65d