A genome‐wide association study of obstructive heart defects among participants in the National Birth Defects Prevention Study

Authors :: Sara R, Rashkin
Mario, Cleves
Gary M, Shaw
Wendy N, Nembhard
Eirini, Nestoridi
Mary M, Jenkins
Paul A, Romitti
Xiang-Yang, Lou
Marilyn L, Browne
Laura E, Mitchell
Andrew F, Olshan
Kevin, Lomangino
Sudeepa, Bhattacharyya
John S, Witte
Charlotte A, Hobbs
Source :: American Journal of Medical Genetics Part A. 188:2303-2314
Publication Year :: 2022
Publisher :: Wiley, 2022.
Abstract: Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures, genetic susceptibilities, and epigenetic phenomena. A genome-wide association study was conducted in National Birth Defects Prevention Study participants (N

Subjects :: Heart Defects, Congenital
Case-Control Studies
Genetics
Humans
Infant
Female
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Genetics (clinical)
Genome-Wide Association Study

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