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The association between physical activity and atrial fibrillation applying the Heaviside function in survival analysis: the Multi-Ethnic Study of Atherosclerosis
- Source :
- Epidemiology and Health, Vol 39 (2017), Epidemiology and Health
- Publication Year :
- 2017
- Publisher :
- Korean Society of Epidemiology, 2017.
-
Abstract
- Objectives Although the effect of physical activity (PA) on the incidence of atrial fibrillation (AF) has been studied, contradictory results have been reported. Such discrepancies may reflect the different effects of various types of PA upon AF, as well as gender interactions. Therefore, we aimed to evaluate the associations of PA types (total, moderate/vigorous, and intentional), as well as walking pace, with AF risk in men and women. Methods Using the Multi-Ethnic Study of Atherosclerosis Typical Week Physical Activity Survey, 3 PA measures and walking pace were calculated among 6,487 men and women aged 45-84 years. The incidence of AF over approximately 11 years of follow-up was ascertained. The association of each PA measure and walking pace with AF incidence was estimated using multivariable Cox proportional hazard models. An extended Cox model with Heaviside functions (hv) of time was used to estimate the effects of time-varying covariates. Results During 11 years of follow-up (49,557 person-years), 242 new AF cases occurred. The incidence rate of AF was 48.83 per 10,000 person-years. The proportional hazard (PH) assumption for total PA among women was not met; hence, we used the hv to calculate the hazard ratio. Total PA in women in the hv2 analysis was negatively associated with AF in all 3 models, although for hv1 no significant association was observed. The PH assumption for walking pace among men was not met, and none of the hv showed a statistically significant association between walking pace and AF in men. Conclusions These results suggest that PA is inversely associated with AF in women.
- Subjects :
- Male
medicine.medical_specialty
Ethnic group
lcsh:Medicine
030204 cardiovascular system & hematology
Iran
Arrhythmias
Walking speed
03 medical and health sciences
0302 clinical medicine
Internal medicine
Surveys and Questionnaires
medicine
Humans
030212 general & internal medicine
Sex Distribution
Association (psychology)
Exercise
Survival analysis
Aged
Aged, 80 and over
Proportional hazards model
business.industry
Incidence (epidemiology)
Incidence
Hazard ratio
lcsh:R
Atrial fibrillation
General Medicine
Middle Aged
medicine.disease
Survival Analysis
Preferred walking speed
Cardiology
Original Article
Female
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 20927193
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Epidemiology and Health
- Accession number :
- edsair.doi.dedup.....4d489cfb5889f5cd2d091de662d82273