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Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018), Nature Communications
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- The role of somatostatin interneurons in nucleus accumbens (NAc), a key brain reward region, remains poorly understood due to the fact that these cells account for<br />While making up a small percentage of neurons in the nucleus accumbens, somatostatin interneurons may have important function in dopamine- and addiction-related behavior. Here, Ribeiro and colleagues show that somatostatin interneurons regulate behavioral responses to cocaine with physiological and transcriptomic changes.
- Subjects :
- Male
0301 basic medicine
genetic structures
Proto-Oncogene Proteins c-jun
General Physics and Astronomy
Nucleus Accumbens
Transcriptome
Mice
0302 clinical medicine
Cocaine
lcsh:Science
Neurons
education.field_of_study
Multidisciplinary
musculoskeletal, neural, and ocular physiology
Gene Transfer Techniques
Brain
Adaptation, Physiological
Somatostatin
Brain stimulation reward
Locomotion
hormones, hormone substitutes, and hormone antagonists
medicine.drug
endocrine system
Science
Population
Optogenetics
Biology
Nucleus accumbens
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Reward
Interneurons
Dopamine
medicine
Animals
education
Sequence Analysis, RNA
Gene Expression Profiling
General Chemistry
Mice, Inbred C57BL
Electrophysiology
030104 developmental biology
Gene Expression Regulation
nervous system
lcsh:Q
Neuroscience
030217 neurology & neurosurgery
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....4d4c8cb395680bf1409a7c2b5697ab86