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Persistent negative symptoms in recent-onset psychosis: Relationship to treatment response and psychosocial functioning
- Source :
- European Neuropsychopharmacology. 34:76-86
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Negative symptoms are associated with poor clinical and psychosocial outcome in schizophrenia. Their prevalence and identification in first-episode patients remains controversial. In a large cohort of patients in the early stage of schizophrenia, schizophreniform or schizoaffective disorder, we investigated, over the different phases of the OPTiMiSE trial (baseline, 4, 10 and 22 weeks of treatment), the prevalence of negative symptoms of moderate severity, unconfounded by depression and extrapyramidal symptoms at baseline. Moreover, we assessed symptomatic remission, attrition rate and psychosocial functioning in subjects with short-term (4 weeks) persistent unconfounded negative symptoms (PNS) and in those with negative symptoms that did not persist at follow-up and/or were confounded at baseline (N-PNS). Negative symptoms of moderate severity were observed in 59% of subjects at baseline. They were associated with worse psychosocial functioning and longer duration of psychosis at intake in the study. Eleven percent of subjects had PNS unconfounded at baseline and 7.9% had PNS unconfounded at both baseline and end of 4-week treatment. Psychosocial functioning was comparable in PNS and N-PNS subjects at baseline but it was significantly worse in the former group after 4-weeks. PNS subjects showed lower remission and higher attrition rates at the end of all treatment phases. Fifty-six percent of subjects completing phase 3 (clozapine treatment) had PNS, and 60% of them were non-remitters at the end of this phase. The presence of short-term PNS during the first phases of psychosis was associated with poor clinical outcome and resistance to antipsychotic treatment, including clozapine.
- Subjects :
- Adult
Male
medicine.medical_specialty
Psychosis
Treatment response
Schizoaffective disorder
Cohort Studies
Young Adult
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Extrapyramidal symptoms
Internal medicine
medicine
Humans
Pharmacology (medical)
Biological Psychiatry
Depression (differential diagnoses)
Clozapine
Outcome
Pharmacology
business.industry
Persistent negative symptoms
medicine.disease
030227 psychiatry
First-episode schizophrenia
Psychosocial Functioning
Psychiatry and Mental health
Treatment Outcome
Psychotic Disorders
nervous system
Neurology
Schizophrenia
Female
Schizophrenic Psychology
Neurology (clinical)
medicine.symptom
business
Psychosocial
030217 neurology & neurosurgery
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 0924977X
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- European Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....4d6d85e1761b2fa7a9c15cdde73af441