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Nucleotide sequence analysis of the long terminal repeat of human T-cell leukemia virus type II
- Source :
- Proceedings of the National Academy of Sciences. 81:1079-1083
- Publication Year :
- 1984
- Publisher :
- Proceedings of the National Academy of Sciences, 1984.
-
Abstract
- The nucleotide sequence of the human T-cell leukemia virus type II (HTLV-II) long terminal repeat (LTR) and its surrounding regions were determined. Our results show the following structural features: (i) the LTR is 763 base pairs (bp) in length and consists of 314 +/- 1 bp of region U3, 248 +/- 1 bp of region R, and 201 bp of region U5; (ii) the terminal nucleotides in the LTR form an inverted repeat of T-G.....C-A; (iii) 6-bp direct repeats of cellular sequences flanking the provirus were present; and (iv) the putative functional signals for initiation or termination of viral RNA synthesis were identified. Comparison of the HTLV-II LTR sequence with that previously published for adult T-cell leukemia virus (ATLV; HTLV-I) shows that the LTRs are distinct. Some small regions are conserved between HTLV-II and ATLV, involving sequences important for transcription and a sequence of 21 nucleotides repeated three times in U3. This 21-bp repeat may be important in regulating viral transcription in lymphoid cells.
- Subjects :
- Genetics
Leukemia, Hairy Cell
Multidisciplinary
Base Sequence
Genes, Viral
Base pair
Inverted repeat
T-Lymphocytes
viruses
Nucleic acid sequence
DNA Restriction Enzymes
Provirus
Biology
Deltaretrovirus
Molecular biology
Long terminal repeat
Virus
Transcription (biology)
DNA, Viral
Humans
Direct repeat
Cloning, Molecular
Research Article
Repetitive Sequences, Nucleic Acid
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....4d86ad885a9c8ec424b24df4e21b639a