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TREM1-ors shake the brain and gut after stroke
- Source :
- Nature immunology 20(8), 950-952 (2019). doi:10.1038/s41590-019-0443-9
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- A new report shows that upregulation of the receptor TREM1 on macrophages and neutrophils, dependent on the adrenergic nervous system, links stroke to systemic inflammation and gut barrier dysfunction, which result in bacterial translocation and exacerbation of neurological damage.
- Subjects :
- 0301 basic medicine
Exacerbation
Immunology
Bacterial translocation
Systemic inflammation
Mice
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
cytology [Intestinal Mucosa]
Animals
Humans
Immunology and Allergy
Medicine
immunology [Intestinal Mucosa]
ddc:610
Receptor
Stroke
pathology [Inflammation]
immunology [Neutrophils]
metabolism [Triggering Receptor Expressed on Myeloid Cells-1]
Gut barrier
business.industry
cytology [Brain]
Adrenergic nervous system
immunology [Macrophages]
TREM1 protein, human
medicine.disease
Triggering Receptor Expressed on Myeloid Cells-1
030104 developmental biology
pathology [Stroke]
immunology [Brain]
medicine.symptom
business
030215 immunology
Subjects
Details
- ISSN :
- 15292916 and 15292908
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Nature Immunology
- Accession number :
- edsair.doi.dedup.....4d88f03a4e402ca634229982d7a3c75c