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Systematic Review and Meta-analysis of the Impact of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) on Cytological Diagnosis and Thyroid Cancer Prevalence
- Source :
- Endocrine Pathology. 30:189-200
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- A re-named diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) likely impacts the prevalence of thyroid cancer and risk of malignancy in populations based on the established Bethesda System of Reporting Thyroid Cytopathology (TBSRTC). This study was done to investigate the prevalence and cytological distribution of NIFTP. PRISMA guided systematic review was done from a database search of Pubmed, EMBASE, and Medline using the search terms "non-invasive follicular thyroid neoplasm with papillary-like nuclear features", "non-invasive follicular variant of papillary carcinoma", "niftp", and "Bethesda" until November 2018. Original articles with surgically proven diagnoses of NIFTP using strict NIFTP criteria were included. Twenty-nine studies with 1563 cases of NIFTP were included. The pooled prevalence of NIFTP in cases which would be classified previously as the follicular variant of papillary thyroid cancer (FVPTC) and papillary thyroid cancer (PTC) were 43.5% (95% CI 33.5-54.0%) and 4.4% (95% CI 2.0-9.0%) respectively. The pooled TBSRTC distribution of cases diagnosed as NIFTP was: from the non-diagnostic category 3.6% (95% CI 2.4-5.3%), benign 10.0% (95% CI 7.2-13.6%), AUS/FLUS 34.2% (95% CI 28.2-40.8%), FN/SFN 22.7% (95% CI 17.2-29.4%), suspicious for malignancy 22.4% (95% CI 17.7-27.9%), and malignant 7.5% (95% CI 4.2-12.9%). While a significant reduction in FVPTC prevalence is anticipated, a modest reduction of PTC prevalence is also expected with adoption of the NIFTP terminology that would be distributed mainly among lesions classified as indeterminate thyroid nodules. Further studies are needed to identify unique clinical characteristics of these lesions preoperatively.
- Subjects :
- Thyroid nodules
medicine.medical_specialty
Cytodiagnosis
Endocrinology, Diabetes and Metabolism
Biopsy, Fine-Needle
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features
Bethesda system
030209 endocrinology & metabolism
Carcinoma, Papillary, Follicular
medicine.disease_cause
Gastroenterology
Pathology and Forensic Medicine
Papillary thyroid cancer
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Endocrinology
Predictive Value of Tests
Internal medicine
Prevalence
medicine
Humans
Thyroid Neoplasms
Thyroid Nodule
Thyroid cancer
Thyroid neoplasm
Cell Nucleus
medicine.diagnostic_test
business.industry
Thyroid
General Medicine
medicine.disease
medicine.anatomical_structure
Thyroid Cancer, Papillary
Cytopathology
030220 oncology & carcinogenesis
Guideline Adherence
business
Subjects
Details
- ISSN :
- 15590097 and 10463976
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Endocrine Pathology
- Accession number :
- edsair.doi.dedup.....4d8d34e0bfacc2a40242495a88d53e9c