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Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?

Authors :
Arif B. Ekici
Mi Kyung Kim
Dong Young Noh
Keun-Young Yoo
Camilla Wendt
Rebecca Mayes
Anna H. Wu
Lauren R. Teras
Stig E. Bojesen
Henrik Flyger
Angela Cox
Melissa C. Southey
Wanqing Wen
Volker Arndt
Chen-Yang Shen
Soo Hwang Teo
Pascal Guénel
Robert Winqvist
Natalia Bogdanova
Hidemi Ito
Chiu-Chen Tseng
Heli Nevanlinna
Simon S. Cross
Yon Ko
Jingmei Li
Mehdi Manoochehri
Peter A. Fasching
Renske Keeman
Keitaro Matsuo
Paul D.P. Pharoah
Nan Song
Alpa V. Patel
Manjeet K. Bolla
Jong Won Lee
Javier Benitez
Anthony J. Swerdlow
Carl Blomqvist
Jaesung Choi
Sei Hyun Ahn
Bernadette A M Heemskerk-Gerritsen
Seokang Chung
Alison M. Dunning
Diether Lambrechts
James V. Lacey
Hermann Brenner
Reiner Hoppe
Wonshik Han
Joe Dennis
Kenneth Muir
Don M. Conroy
Rebecca Roylance
Michael Jones
Thilo Dörk
Pei Ei Wu
Mitul Shah
Arto Mannermaa
Patricia Harrington
Sue K. Park
Vessela N. Kristensen
Bernardo Bonanni
Jaana M. Hartikainen
Rob A. E. M. Tollenaar
Qin Wang
Paolo Radice
Mikael Hartman
Joo Yong Park
Adinda Baten
Irene L. Andrulis
Douglas F. Easton
Sun Ha Jee
Annika Lindblom
Daehee Kang
Ji Yeob Choi
Elinor J. Sawyer
Fergus J. Couch
Ute Hamann
Kyriaki Michailidou
Anna González-Neira
Thérèse Truong
Olivia Fletcher
Per Hall
Artitaya Lophatananon
Nur Aishah Taib
Maria Elena Martinez
Janet E. Olson
Kamila Czene
John L. Hopper
kConFab Investigators
Nichola Johnson
Christopher A. Haiman
Mervi Grip
Marjanka K. Schmidt
Song, Nan [0000-0002-9182-1060]
Park, Sue K [0000-0001-5002-9707]
Kim, Mi Kyung [0000-0001-5279-4162]
Dennis, Joe [0000-0003-4591-1214]
Michailidou, Kyriaki [0000-0001-7065-1237]
Hall, Per [0000-0002-5640-9126]
Matsuo, Keitaro [0000-0003-1761-6314]
Ito, Hidemi [0000-0002-8023-4581]
Keeman, Renske [0000-0002-5452-9933]
Schmidt, Marjanka K [0000-0002-2228-429X]
Fasching, Peter A [0000-0003-4885-8471]
Brenner, Hermann [0000-0002-6129-1572]
Arndt, Volker [0000-0001-9320-8684]
Hartikainen, Jaana M [0000-0001-8267-1905]
Dörk, Thilo [0000-0002-9458-0282]
Bogdanova, Natalia V [0000-0002-9736-4593]
Johnson, Nichola [0000-0002-8230-5662]
Nevanlinna, Heli [0000-0002-0916-2976]
Heemskerk-Gerritsen, Bernadette AM [0000-0002-9724-6693]
Bonanni, Bernardo [0000-0003-3589-2128]
Apollo - University of Cambridge Repository
Medicum
HUS Comprehensive Cancer Center
Department of Oncology
Clinicum
Helsinki University Hospital Area
University of Helsinki
HUS Gynecology and Obstetrics
Department of Obstetrics and Gynecology
Park, Sue K. [0000-0001-5002-9707]
Schmidt, Marjanka K. [0000-0002-2228-429X]
Fasching, Peter A. [0000-0003-4885-8471]
Hartikainen, Jaana M. [0000-0001-8267-1905]
Bogdanova, Natalia V. [0000-0002-9736-4593]
Heemskerk-Gerritsen, Bernadette A. M. [0000-0002-9724-6693]
Medical Oncology
Source :
Cancers, Cancers, vol 13, iss 10, Cancers, 13(10). MDPI, Cancers, Vol 13, Iss 2370, p 2370 (2021), Volume 13, Issue 10, Cancers, 13(10):2370. Multidisciplinary Digital Publishing Institute (MDPI), Park, J Y, Choi, J Y, Choi, J, Chung, S, Song, N, Park, S K, Han, W, Noh, D Y, Ahn, S H, Lee, J W, Kim, M K, Jee, S H, Wen, W, Bolla, M K, Wang, Q, Dennis, J, Michailidou, K, Shah, M, Conroy, D M, Harrington, P A, Mayes, R, Czene, K, Hall, P, Teras, L R, Patel, A V, Couch, F J, Olson, J E, Sawyer, E J, Roylance, R, Bojesen, S E, Flyger, H, Lambrechts, D, Baten, A, Matsuo, K, Ito, H, Guénel, P, Truong, T, Keeman, R, Schmidt, M K, Wu, A H, Tseng, C C, Cox, A, Cross, S S, Investigators, K, Andrulis, I L, Hopper, J L, Southey, M C, Wu, P E, Shen, C Y, Fasching, P A, Ekici, A B, Muir, K, Lophatananon, A, Brenner, H, Arndt, V, Jones, M E, Swerdlow, A J, Hoppe, R, Ko, Y D, Hartman, M, Li, J, Mannermaa, A, Hartikainen, J M, Benitez, J, González-Neira, A, Haiman, C A, Dörk, T, Bogdanova, N V, Teo, S H, Taib, N A M, Fletcher, O, Johnson, N, Grip, M, Winqvist, R, Blomqvist, C, Nevanlinna, H, Lindblom, A, Wendt, C, Kristensen, V N, Collaborators, N B C S, Tollenaar, R A E M, Heemskerk-Gerritsen, B A M, Radice, P, Bonanni, B, Hamann, U, Manoochehri, M, Lacey, J V, Martinez, M E, Dunning, A M, Pharoah, P D P, Easton, D F, Yoo, K Y & Kang, D 2021, ' Gene-environment interactions relevant to estrogen and risk of breast cancer : Can gene-environment interactions be detected only among candidate snps from genome-wide association studies? ', Cancers, vol. 13, no. 10, 2370 . https://doi.org/10.3390/cancers13102370
Publication Year :
2021

Abstract

Simple Summary Breast cancer is the most common cancer in females worldwide. To date, many gene-environment interaction (GxE) studies have been conducted to better understand how genetic factors combine with environmental factors to influence risk. However, previous studies have not found or found only a few interactions by using SNPs which were discovered from genome-wide association studies and have been conducted, for the most part, within European populations. In this study, we focused on estrogen-related lifestyle factors that have been identified for breast cancer, including several well-established reproductive factors that are mediated by hormonal mechanisms. We aimed to examine whether there are any gene and environmental factor interactions related to estrogen exposure or metabolism using a candidate approach in Korean women. We found two interactions in this study, although they were not replicated in the independent large consortium data. These findings suggest specificity in Koreans for breast cancer risk. In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 x 10(-3)). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 x 10(-4)). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.

Details

ISSN :
20726694
Volume :
13
Issue :
10
Database :
OpenAIRE
Journal :
Cancers
Accession number :
edsair.doi.dedup.....4d914260585611607cc3130d66cdeb39