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Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?
- Source :
- Cancers, Cancers, vol 13, iss 10, Cancers, 13(10). MDPI, Cancers, Vol 13, Iss 2370, p 2370 (2021), Volume 13, Issue 10, Cancers, 13(10):2370. Multidisciplinary Digital Publishing Institute (MDPI), Park, J Y, Choi, J Y, Choi, J, Chung, S, Song, N, Park, S K, Han, W, Noh, D Y, Ahn, S H, Lee, J W, Kim, M K, Jee, S H, Wen, W, Bolla, M K, Wang, Q, Dennis, J, Michailidou, K, Shah, M, Conroy, D M, Harrington, P A, Mayes, R, Czene, K, Hall, P, Teras, L R, Patel, A V, Couch, F J, Olson, J E, Sawyer, E J, Roylance, R, Bojesen, S E, Flyger, H, Lambrechts, D, Baten, A, Matsuo, K, Ito, H, Guénel, P, Truong, T, Keeman, R, Schmidt, M K, Wu, A H, Tseng, C C, Cox, A, Cross, S S, Investigators, K, Andrulis, I L, Hopper, J L, Southey, M C, Wu, P E, Shen, C Y, Fasching, P A, Ekici, A B, Muir, K, Lophatananon, A, Brenner, H, Arndt, V, Jones, M E, Swerdlow, A J, Hoppe, R, Ko, Y D, Hartman, M, Li, J, Mannermaa, A, Hartikainen, J M, Benitez, J, González-Neira, A, Haiman, C A, Dörk, T, Bogdanova, N V, Teo, S H, Taib, N A M, Fletcher, O, Johnson, N, Grip, M, Winqvist, R, Blomqvist, C, Nevanlinna, H, Lindblom, A, Wendt, C, Kristensen, V N, Collaborators, N B C S, Tollenaar, R A E M, Heemskerk-Gerritsen, B A M, Radice, P, Bonanni, B, Hamann, U, Manoochehri, M, Lacey, J V, Martinez, M E, Dunning, A M, Pharoah, P D P, Easton, D F, Yoo, K Y & Kang, D 2021, ' Gene-environment interactions relevant to estrogen and risk of breast cancer : Can gene-environment interactions be detected only among candidate snps from genome-wide association studies? ', Cancers, vol. 13, no. 10, 2370 . https://doi.org/10.3390/cancers13102370
- Publication Year :
- 2021
-
Abstract
- Simple Summary Breast cancer is the most common cancer in females worldwide. To date, many gene-environment interaction (GxE) studies have been conducted to better understand how genetic factors combine with environmental factors to influence risk. However, previous studies have not found or found only a few interactions by using SNPs which were discovered from genome-wide association studies and have been conducted, for the most part, within European populations. In this study, we focused on estrogen-related lifestyle factors that have been identified for breast cancer, including several well-established reproductive factors that are mediated by hormonal mechanisms. We aimed to examine whether there are any gene and environmental factor interactions related to estrogen exposure or metabolism using a candidate approach in Korean women. We found two interactions in this study, although they were not replicated in the independent large consortium data. These findings suggest specificity in Koreans for breast cancer risk. In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 x 10(-3)). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 x 10(-4)). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
Candidate gene
PREMENOPAUSAL
medicine.medical_treatment
STEROID-RECEPTOR COACTIVATOR-1
Genome-wide association study
0302 clinical medicine
HEIGHT
estrogen
2.1 Biological and endogenous factors
RACIAL-DIFFERENCES
EPIDEMIOLOGY
Gene–environment interaction
Aetiology
RC254-282
Cancer
education.field_of_study
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Hormone replacement therapy (menopause)
3. Good health
030220 oncology & carcinogenesis
Life Sciences & Biomedicine
medicine.medical_specialty
ESR1 MUTATIONS
SUSCEPTIBILITY LOCI
Population
Oncology and Carcinogenesis
3122 Cancers
Single-nucleotide polymorphism
Biology
Article
03 medical and health sciences
Breast cancer
breast cancer
SDG 3 - Good Health and Well-being
Clinical Research
Internal medicine
medicine
Genetics
ddc:610
education
POLYMORPHISMS
Science & Technology
METABOLISM PATHWAY GENES
Prevention
HORMONE REPLACEMENT THERAPY
Human Genome
medicine.disease
gene-environment interaction
Minor allele frequency
030104 developmental biology
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 13
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....4d914260585611607cc3130d66cdeb39
- Full Text :
- https://doi.org/10.3390/cancers13102370