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New therapeutic strategies for IPF: Based on the 'phagocytosis-secretion-immunization' network regulation mechanism of pulmonary macrophages
- Source :
- Biomedicine & Pharmacotherapy, Vol 118, Iss, Pp-(2019)
- Publication Year :
- 2019
-
Abstract
- Pulmonary fibrosis is a chronic and progressive interstitial lung disease of known and unknown etiology. Over the past decades, macrophages have been recognized to play a significant role in IPF pathogenesis. According to their anatomical loci, macrophages can be divided to alveolar macrophages (AMs) subtypes and interstitial macrophages subtypes (IMs) with different responsibility in the damage defense response. Depending on diverse chemokines and cytokines in local microenvironments, macrophages can be induced and polarized to either classically activated (M1) or alternatively activated (M2) phenotypes in different stages of immunity. Therefore, we hypothesize that there is a “phagocytosis-secretion-immunization” network regulation of pulmonary macrophages related to a number of chemokines and cytokines. In this paper, we summarize and discuss the role of chemokines and cytokines involved in the “phagocytosis-secretion-immunization” network regulation mechanism of pulmonary macrophages, pointing toward novel therapeutic approaches based on the network target regulation in the field. Therapeutic strategies focused on modifying the chemokines, cytokines and the network are promising for the pharmacotherapy of IPF. Some Traditional Chinese medicines may have more superiorities in delaying the progression of pulmonary fibrosis for their multi-target activities of this network regulation.
- Subjects :
- 0301 basic medicine
Chemokine
Network regulation
Phagocytosis
Pulmonary Fibrosis
RM1-950
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Immunity
Traditional Chinese medicines
Pulmonary fibrosis
Macrophages, Alveolar
medicine
Humans
Secretion
Pharmacology
biology
Mechanism (biology)
business.industry
Macrophages
Interstitial lung disease
General Medicine
Fibroblasts
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Immunology
biology.protein
Cytokines
Immunization
Therapeutics. Pharmacology
business
Subjects
Details
- ISSN :
- 19506007
- Volume :
- 118
- Database :
- OpenAIRE
- Journal :
- Biomedicinepharmacotherapy = Biomedecinepharmacotherapie
- Accession number :
- edsair.doi.dedup.....4d94ac49058f536eef3650398bf1cb34