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Risk factors for active tuberculosis in 938 QuantiFERON-positive schoolchildren in Mongolia: a community-based cross-sectional study
- Source :
- BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-9 (2019), BMC Infectious Diseases
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background There is controversy regarding the relative influence of ‘exogenous’ versus ‘endogenous’ factors on the risk of progression from latent tuberculosis infection to active tuberculosis (TB) disease in children. Methods We conducted a cross-sectional analysis to identify risk factors for active tuberculosis in QuantiFERON®-TB Gold (QFT-G)-positive children aged 6–13 years attending 18 schools in Ulaanbaatar, Mongolia. Children underwent clinical and radiological screening for active tuberculosis, and data relating to potential risk factors for disease progression were collected by questionnaire and determination of serum 25-hydroxyvitamin D (25[OH]D) concentrations. Risk ratios were calculated using generalized estimating equations with adjustment for potential confounders. Results 129/938 (13.8%) QFT-positive children were diagnosed with active tuberculosis. Risk of active tuberculosis was independently associated with household exposure to pulmonary TB (adjusted risk ratio [aRR] 2.40, 95% CI 1.74 to 3.30, P
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
QuantiFERON®-TB gold
Tuberculosis
Adolescent
Cross-sectional study
030106 microbiology
Disease
lcsh:Infectious and parasitic diseases
QuantiFERON
03 medical and health sciences
0302 clinical medicine
Latent Tuberculosis
Surveys and Questionnaires
Internal medicine
Odds Ratio
medicine
Vitamin D and neurology
Humans
Mass Screening
lcsh:RC109-216
030212 general & internal medicine
Vitamin D
Child
Tuberculosis, Pulmonary
Children
2. Zero hunger
Hematologic Tests
Latent tuberculosis
business.industry
Smoking
Confounding
Mongolia
medicine.disease
Mycobacterium bovis
3. Good health
Cross-Sectional Studies
Infectious Diseases
Risk factors
Relative risk
Disease Progression
Female
business
Research Article
Subjects
Details
- ISSN :
- 14712334
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- BMC Infectious Diseases
- Accession number :
- edsair.doi.dedup.....4d9d07458a137f5ca72b31a078a9fe78