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Phorbol esters as probes of the regulation of thyrotropin secretion
- Source :
- Biochemical and Biophysical Research Communications. 125:353-359
- Publication Year :
- 1984
- Publisher :
- Elsevier BV, 1984.
-
Abstract
- 12-0-Tetradecanoylphorbol 13-acetate and thyrotropin releasing hormone were compared as thyrotropin secretagogues in cultured rat pituitary cells. The maximal secretion evoked by the former was only half that evoked by the latter. A23187 plus 12-0-tetradecanoylphorbol 13-acetate together produced as large a response as thyrotropin releasing hormone. Triiodothyronine inhibited phorbol ester-induced thyrotropin secretion, and this inhibition required protein synthesis.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
endocrine system diseases
Biophysics
Thyrotropin
Thyrotropin-releasing hormone
Biochemistry
chemistry.chemical_compound
Pituitary Gland, Anterior
Thyrotropin-releasing hormone receptor
Internal medicine
Phorbol Esters
medicine
Protein biosynthesis
Pi
Animals
Phorbol esters
Secretion
Cycloheximide
Thyrotropin-Releasing Hormone
Molecular Biology
Calcimycin
Triiodothyronine
Dose-Response Relationship, Drug
Rats, Inbred Strains
Cell Biology
Phorbols
Rats
Endocrinology
chemistry
Phorbol
Tetradecanoylphorbol Acetate
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....4da68eb7157701672e19d44a1842a659