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Oncoprotein changes in the flat lesions with atypia and invasive neoplasms of the urinary bladder
- Source :
- Oncology reports. 8(3)
- Publication Year :
- 2001
-
Abstract
- We analyzed six cystectomized specimens diagnosed as transitional cell carcinoma by immunohistochemical evaluation to determine the presence of c-erbB2, transforming growth factor-alpha (TGF-alpha), c-myc, c-fos, and c-fms. Representative sections of flat lesions with atypia (e.g., reactive atypia, dysplasia, and carcinoma in situ) and invasive neoplasms (transitional cell carcinoma, TCC) were selected for each cystectomy specimen according to the new WHO/ISUP classification. The average percentage of cells found positive for c-erbB2 were 16.3%, 45.5%, 46.1% and 67.7% in the reactive atypia, dysplasia, carcinoma in situ, and invasive TCC, respectively. The average percentage of cells found positive for TGF-alpha were 9.7%, 13.3%, 13.5%, 30.3%, respectively. The cells were negative for the oncoproteins c-myc and c-fos. The average percentage of cells found positive for the oncoprotein c-fms was 10.6%, 15.5%, 16.7%, and 45.5% respectively. The results of this study indicated that various oncoproteins are expressed differently. c-erbB2, TGF-alpha and c-fms expression was gradually increased during tumorous progression of the urothelium from reactive atypia to invasive carcinoma. The presence of c-erbB2, TGF-alpha and c-fms is an important marker for detection of an early precursor lesions of invasive carcinoma. However, c-myc and c-fos were not expressed in the urothelial reactive atypia and dysplasia and did not correlate with tumor progression.
- Subjects :
- Cancer Research
Pathology
medicine.medical_specialty
Receptor, ErbB-2
medicine.medical_treatment
Receptor, Macrophage Colony-Stimulating Factor
Biology
Cystectomy
Immunoenzyme Techniques
Proto-Oncogene Proteins c-myc
medicine
Atypia
Humans
Neoplasm Invasiveness
Urothelium
skin and connective tissue diseases
Growth Substances
neoplasms
Oncogene Proteins
Carcinoma, Transitional Cell
Urinary bladder
Epidermal Growth Factor
Carcinoma in situ
General Medicine
Transforming Growth Factor alpha
medicine.disease
ErbB Receptors
Transitional cell carcinoma
medicine.anatomical_structure
Oncology
Urinary Bladder Neoplasms
Dysplasia
Tumor progression
Disease Progression
Proto-Oncogene Proteins c-fos
Carcinoma in Situ
Subjects
Details
- ISSN :
- 1021335X
- Volume :
- 8
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Oncology reports
- Accession number :
- edsair.doi.dedup.....4da6cbd9749f7523c66f1469ce9dfe31