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Phenotype in combination with genotype improves outcome prediction in acute myeloid leukemia: a report from Children’s Oncology Group protocol AAML0531
- Source :
- Haematologica
- Publication Year :
- 2017
- Publisher :
- Ferrata Storti Foundation, 2017.
-
Abstract
- Diagnostic biomarkers can be used to determine relapse risk in acute myeloid leukemia, and certain genetic aberrancies have prognostic relevance. A diagnostic immunophenotypic expression profile, which quantifies the amounts of distinct gene products, not just their presence or absence, was established in order to improve outcome prediction for patients with acute myeloid leukemia. The immunophenotypic expression profile, which defines each patient's leukemia as a location in 15-dimensional space, was generated for 769 patients enrolled in the Children's Oncology Group AAML0531 protocol. Unsupervised hierarchical clustering grouped patients with similar immunophenotypic expression profiles into eleven patient cohorts, demonstrating high associations among phenotype, genotype, morphology, and outcome. Of 95 patients with inv(16), 79% segregated in Cluster A. Of 109 patients with t(8;21), 92% segregated in Clusters A and B. Of 152 patients with 11q23 alterations, 78% segregated in Clusters D, E, F, G, or H. For both inv(16) and 11q23 abnormalities, differential phenotypic expression identified patient groups with different survival characteristics (P
- Subjects :
- 0301 basic medicine
Oncology
Acute Myeloid Leukemia
medicine.medical_specialty
Myeloid
Adolescent
Genotype
Article
Immunophenotyping
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Cluster Analysis
Humans
Child
Survival analysis
medicine.diagnostic_test
business.industry
Myeloid leukemia
Bone Marrow Examination
Hematology
medicine.disease
Prognosis
Phenotype
Survival Analysis
3. Good health
Clinical trial
Bone marrow examination
Leukemia
Leukemia, Myeloid, Acute
030104 developmental biology
medicine.anatomical_structure
Treatment Outcome
030220 oncology & carcinogenesis
Child, Preschool
Regression Analysis
business
Subjects
Details
- Language :
- English
- ISSN :
- 15928721 and 03906078
- Volume :
- 102
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Haematologica
- Accession number :
- edsair.doi.dedup.....4db4700833fd2452e1f984d55b515573