Back to Search
Start Over
A complier average causal effect analysis of the Stimulant Reduction Intervention using dosed exercise study
- Source :
- Contemporary Clinical Trials Communications, Vol 10, Iss, Pp 1-8 (2018), Contemporary Clinical Trials Communications
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Objective: Exercise is a promising treatment for substance use disorders, yet an intention-to-treat analysis of a large, multi-site study found no reduction in stimulant use for exercise versus health education. Exercise adherence was sub-optimal; therefore, secondary post-hoc complier average causal effects (CACE) analysis was conducted to determine the potential effectiveness of adequately dosed exercise. Method: The STimulant use Reduction Intervention using Dosed Exercise study was a randomized controlled trial comparing a 12 kcal/kg/week (KKW) exercise dose versus a health education control conducted at nine residential substance use treatment settings across the U.S. that are affiliated with the National Drug Abuse Treatment Clinical Trials Network. Participants were sedentary but medically approved for exercise, used stimulants within 30 days prior to study entry, and received a DSM-IV stimulant abuse or dependence diagnosis within the past year. A CACE analysis adjusted to include only participants with a minimum threshold of adherence (at least 8.3 KKW) and using a negative-binomial hurdle model focused on 218 participants who were 36.2% female, mean age 39.4 years (SD = 11.1), and averaged 13.0 (SD = 9.2) stimulant use days in the 30 days before residential treatment. The outcome was days of stimulant use as assessed by the self-reported TimeLine Follow Back and urine drug screen results. Results: The CACE-adjusted analysis found a significantly lower probability of relapse to stimulant use in the exercise group versus the health education group (41.0% vs. 55.7%, p
- Subjects :
- Clinical trials network
Stimulant abuse or dependence
medicine.medical_specialty
STRIDE, STimulant Reduction Intervention using Dosed Exercise
medicine.medical_treatment
UDS, Urine Drug Screens
RTP, Residential Treatment Program
01 natural sciences
Article
law.invention
010104 statistics & probability
03 medical and health sciences
KKW, kilocalories/kilogram/week
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
Intervention (counseling)
medicine
Exercise intervention
030212 general & internal medicine
0101 mathematics
Pharmacology
Stimulant abuse
ITT, Intention-to-Treat
lcsh:R5-920
business.industry
Causal effect
General Medicine
medicine.disease
Clinical trial
Substance abuse
Stimulant
Complier average causal effects
TLFB, Timeline Follow Back
Health education
lcsh:Medicine (General)
business
SUD, Substance Use Disorders
CACE, Complier Average Causal Effect
Subjects
Details
- ISSN :
- 24518654
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Contemporary Clinical Trials Communications
- Accession number :
- edsair.doi.dedup.....4dba845c99ed25189c19ce3b888f8e8e