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Severe and fatal forms of COVID-19 in children

Authors :
Mehdi Oualha
Elodie Salvador
M. Vedrenne
L. de Saint Blanquat
L. Dupic
F. Lesage
C. Heilbronner
Alice Corsia
David Drummond
Florence Moulin
C. de Marcellus
M. Bendavid
G. Chéron
Y. Pinhas
Marion Grimaud
Romain Berthaud
Judith Chareyre
François Angoulvant
Jacques Fourgeaud
Laureline Berteloot
Sylvain Renolleau
Julie Toubiana
Pierre Frange
M. Castelle
Université de Paris (UP)
CHU Necker - Enfants Malades [AP-HP]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)
Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138))
École pratique des hautes études (EPHE)
Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)
Université Paris Cité (UPC)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC)
Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC)
Source :
Archives de Pédiatrie, Archives de Pédiatrie, Elsevier, 2020, 27, pp.235-238. ⟨10.1016/j.arcped.2020.05.010⟩, Indian Journal of Pediatrics, Archives De Pediatrie
Publication Year :
2020
Publisher :
HAL CCSD, 2020.

Abstract

Objectives The aim of this study was to describe severe forms of novel coronavirus disease 2019 in children, including patient characteristics, clinical, laboratory, and imaging findings, as well as the disease management and outcomes. Methods This was a retrospective, single-center, observational study conducted in a pediatric intensive and high-dependency care unit (PICU, HDU) in an urban hospital in Paris. All patients, aged from 1 month to 18 years, admitted for confirmed or highly suspected SARS-CoV-2 were included. Results We analyzed the data of 27 children. Comorbidities (n = 19, 70%) were mainly neurological (n = 7), respiratory, (n = 4), or sickle cell disease (n = 4). SARS-CoV-2 PCR results were positive in 24 children (nasopharyngeal swabs). The three remaining children had a chest CT scan consistent with COVID-19. Respiratory involvement was observed in 24 patients (89%). Supportive treatments were invasive mechanical ventilation (n = 9), catecholamine (n = 4), erythropheresis (n = 4), renal replacement therapy (n = 1), and extracorporeal membrane oxygenation (n = 1). Five children died, of whom three were without past medical history. Conclusion This study highlighted the large spectrum of clinical presentation and time course of disease progression as well as the non-negligible occurrence of pediatric life-threatening and fatal cases of COVID-19 mostly in patients with comorbidities. Additional laboratory investigations are needed to further analyze the mechanism underlying the variability of SARS-Cov-2 pathogenicity in children.

Details

Language :
English
ISSN :
0929693X and 1769664X
Database :
OpenAIRE
Journal :
Archives de Pédiatrie, Archives de Pédiatrie, Elsevier, 2020, 27, pp.235-238. ⟨10.1016/j.arcped.2020.05.010⟩, Indian Journal of Pediatrics, Archives De Pediatrie
Accession number :
edsair.doi.dedup.....4e0a04868336c842c714e8ff800db5c0
Full Text :
https://doi.org/10.1016/j.arcped.2020.05.010⟩