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Severe and fatal forms of COVID-19 in children
- Source :
- Archives de Pédiatrie, Archives de Pédiatrie, Elsevier, 2020, 27, pp.235-238. ⟨10.1016/j.arcped.2020.05.010⟩, Indian Journal of Pediatrics, Archives De Pediatrie
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Objectives The aim of this study was to describe severe forms of novel coronavirus disease 2019 in children, including patient characteristics, clinical, laboratory, and imaging findings, as well as the disease management and outcomes. Methods This was a retrospective, single-center, observational study conducted in a pediatric intensive and high-dependency care unit (PICU, HDU) in an urban hospital in Paris. All patients, aged from 1 month to 18 years, admitted for confirmed or highly suspected SARS-CoV-2 were included. Results We analyzed the data of 27 children. Comorbidities (n = 19, 70%) were mainly neurological (n = 7), respiratory, (n = 4), or sickle cell disease (n = 4). SARS-CoV-2 PCR results were positive in 24 children (nasopharyngeal swabs). The three remaining children had a chest CT scan consistent with COVID-19. Respiratory involvement was observed in 24 patients (89%). Supportive treatments were invasive mechanical ventilation (n = 9), catecholamine (n = 4), erythropheresis (n = 4), renal replacement therapy (n = 1), and extracorporeal membrane oxygenation (n = 1). Five children died, of whom three were without past medical history. Conclusion This study highlighted the large spectrum of clinical presentation and time course of disease progression as well as the non-negligible occurrence of pediatric life-threatening and fatal cases of COVID-19 mostly in patients with comorbidities. Additional laboratory investigations are needed to further analyze the mechanism underlying the variability of SARS-Cov-2 pathogenicity in children.
- Subjects :
- Male
Paris
Pediatrics
medicine.medical_specialty
Adolescent
Coronavirus disease 2019 (COVID-19)
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Pneumonia, Viral
coronavirus
India
Comorbidity
Disease
Severity of Illness Index
Article
Betacoronavirus
03 medical and health sciences
COVID-19 Testing
0302 clinical medicine
Risk Factors
030225 pediatrics
medicine
Extracorporeal membrane oxygenation
Humans
Pediatrics, Perinatology, and Child Health
030212 general & internal medicine
Renal replacement therapy
Disease management (health)
Child
Pandemics
Demography
Retrospective Studies
Mechanical ventilation
Past medical history
Clinical Laboratory Techniques
SARS-CoV-2
business.industry
COVID-19
Infant
Prognosis
3. Good health
Child, Preschool
Pediatrics, Perinatology and Child Health
Disease Progression
Female
Observational study
Coronavirus Infections
business
Scientific Letter
Subjects
Details
- Language :
- English
- ISSN :
- 0929693X and 1769664X
- Database :
- OpenAIRE
- Journal :
- Archives de Pédiatrie, Archives de Pédiatrie, Elsevier, 2020, 27, pp.235-238. ⟨10.1016/j.arcped.2020.05.010⟩, Indian Journal of Pediatrics, Archives De Pediatrie
- Accession number :
- edsair.doi.dedup.....4e0a04868336c842c714e8ff800db5c0
- Full Text :
- https://doi.org/10.1016/j.arcped.2020.05.010⟩