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Nitric oxide and superoxide anion production in monocytes from children exposed to arsenic and lead in region Lagunera, Mexico
- Source :
- Toxicology and Applied Pharmacology. 198:283-290
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- We evaluated in Mexican children environmentally exposed to arsenic and lead monocyte nitric oxide (NO) and superoxide anion production in response to direct activation with interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS). The integrity of Th1-regulated cellular immune response when monocytes were indirectly activated was also evaluated. Most children lived near a primary lead smelter. Lead and arsenic contamination in soil and dust by far exceeded background levels. As levels in water were between 10 and 30 ppb. Most children (93%) had urinary arsenic (AsU) concentrations above 50 microg/l (range 16.75-465.75) and 65% had lead blood levels (PbB) above 10 microg/dl (range 3.47-49.19). Multivariate analyses showed that NO production in monocytes activated indirectly was negatively associated with both PbB and AsU. Superoxide production in directly activated monocytes was negatively associated with AsU but positively associated with PbB. The models including the interaction term for AsU and PbB suggested the possibility of a negative interaction for NO production and a positive interaction for superoxide. There were indications of differential gender-based associations, NO production in indirectly activated monocytes obtained from girls was negatively associated with AsU but not with PbB. Superoxide production was positively associated with PbB in both directly and indirectly activated monocytes from boys but the latter was negatively associated with AsU. These effects are consistent with immune system abnormalities observed in human populations exposed to Pb or As. Further studies in larger populations are required to characterize As and Pb interactions and the mechanism(s) underlying the observed effects.
- Subjects :
- Lipopolysaccharides
Male
medicine.medical_specialty
Lipopolysaccharide
chemistry.chemical_element
Nitric Oxide
Toxicology
Monocytes
Arsenic
Nitric oxide
Interferon-gamma
chemistry.chemical_compound
Immune system
Superoxides
Internal medicine
medicine
Humans
Child
Mexico
Pharmacology
Superoxide
Monocyte
Arsenic contamination of groundwater
Cross-Sectional Studies
medicine.anatomical_structure
Endocrinology
Lead
chemistry
Immunology
Toxicity
Environmental Pollutants
Female
Subjects
Details
- ISSN :
- 0041008X
- Volume :
- 198
- Database :
- OpenAIRE
- Journal :
- Toxicology and Applied Pharmacology
- Accession number :
- edsair.doi.dedup.....4e0d22f253c625a14b50298ca881aa29