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The implementation of a national paediatric oncology protocol for neuroblastoma in South Africa

Authors :
Jan du Plessis
Anel van Zyl
Jaques van Heerden
Biance Rowe
G. P. Hadley
D Harrison
Johani Johani
Janet Poole
Mariana Kruger
Barry van Emmenes
Ané Büchner
Ronelle Uys
Mairi Bassingthwaighte
Gita Naidu
Nicolene Moonsamy
Marc Hendricks
SACCSG Neuroblastoma Workgroup
Source :
Cancer: causes and control, Cancer Causes & Control
Publication Year :
2021

Abstract

Purpose The aim of the World Health Organization-International Paediatric Oncology Society is to improve childhood cancer survival in low- and middle-income countries to 60% by 2030. This can be achieved using standardised evidence-based national treatment protocols for common childhood cancers. The aim of the study was to describe the development and implementation of the SACCSG NB-2017 neuroblastoma (NB) treatment protocol as part of the treatment harmonisation process of the South African Children’s Cancer Study Group. Methods The Consolidated Framework for Implementation Research was used to identify factors that could influence the implementation of the national NB protocol as a health care intervention. The evaluation was done according to five interactive domains for implementation: intervention characteristics, inner setting, outer setting, individual or team characteristics and the implementation process. Results The protocol was developed over 26 months by 26 physicians involved in childhood cancer management. The process included an organisational phase, a resource identification phase, a development phase and a research ethics approval phase. Challenges included nationalised inertia, variable research ethical approval procedures with delays and uncoordinated clinical trial implementation. Conclusion The implementation of the national NB protocol demonstrated the complexity of the implementation of a national childhood cancer treatment protocol. However, standardised paediatric cancer treatment protocols based on local expertise and resources in limited settings are feasible. Supplementary Information The online version contains supplementary material available at 10.1007/s10552-021-01424-2.

Details

Language :
English
ISSN :
09575243
Database :
OpenAIRE
Journal :
Cancer: causes and control
Accession number :
edsair.doi.dedup.....4e168011136dcdbb1aabbcdfeffd8f61