Back to Search
Start Over
The implementation of a national paediatric oncology protocol for neuroblastoma in South Africa
- Source :
- Cancer: causes and control, Cancer Causes & Control
- Publication Year :
- 2021
-
Abstract
- Purpose The aim of the World Health Organization-International Paediatric Oncology Society is to improve childhood cancer survival in low- and middle-income countries to 60% by 2030. This can be achieved using standardised evidence-based national treatment protocols for common childhood cancers. The aim of the study was to describe the development and implementation of the SACCSG NB-2017 neuroblastoma (NB) treatment protocol as part of the treatment harmonisation process of the South African Children’s Cancer Study Group. Methods The Consolidated Framework for Implementation Research was used to identify factors that could influence the implementation of the national NB protocol as a health care intervention. The evaluation was done according to five interactive domains for implementation: intervention characteristics, inner setting, outer setting, individual or team characteristics and the implementation process. Results The protocol was developed over 26 months by 26 physicians involved in childhood cancer management. The process included an organisational phase, a resource identification phase, a development phase and a research ethics approval phase. Challenges included nationalised inertia, variable research ethical approval procedures with delays and uncoordinated clinical trial implementation. Conclusion The implementation of the national NB protocol demonstrated the complexity of the implementation of a national childhood cancer treatment protocol. However, standardised paediatric cancer treatment protocols based on local expertise and resources in limited settings are feasible. Supplementary Information The online version contains supplementary material available at 10.1007/s10552-021-01424-2.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
National Health Programs
Consolidated Framework for Implementation Research
National protocols
South Africa
Neuroblastoma
03 medical and health sciences
0302 clinical medicine
Resource (project management)
Intervention (counseling)
Health care
medicine
Humans
030212 general & internal medicine
Child
Children
Protocol (science)
Original Paper
Research ethics
business.industry
Public health
Antineoplastic Protocols
Infant
Patient Outcome Assessment
Clinical trial
Oncology
Child, Preschool
030220 oncology & carcinogenesis
Family medicine
Female
Implementation research
Human medicine
business
Delivery of Health Care
Subjects
Details
- Language :
- English
- ISSN :
- 09575243
- Database :
- OpenAIRE
- Journal :
- Cancer: causes and control
- Accession number :
- edsair.doi.dedup.....4e168011136dcdbb1aabbcdfeffd8f61