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Expression of MIF, Beclin1, and LC3 in human salivary gland adenoid cystic carcinoma and its prognostic value
- Source :
- Medicine
- Publication Year :
- 2019
- Publisher :
- Wolters Kluwer Health, 2019.
-
Abstract
- Adenoid cystic carcinoma (ACC) is an uncommon salivary gland malignancy with a poor long-term prognosis. Clinical reports show the high rates of local recurrences and distant metastases. This study aimed to investigate the expression of MIF, Beclin1, and light-chain 3 (LC3) in salivary adenoid cystic carcinoma (SACC). Tissue specimens were obtained from 48 salivary glands adenoid cystic carcinoma (SACC) patients and 15 oral squamous cell carcinoma (OSCC) patients. Immunohistochemical staining was performed to estimate the level of LC3, Beclin1, and MIF. All SACC patients were followed up. The Kaplan–Meier method was used to compare the prognosis of patients after treatment. The 3-year, 5 year-, and 10 year-survival rates of the SACC patients were 83.9%, 69.9%, and 46.6%, respectively. MIF, LC3, and Beclin1 in SACC were all obviously over-expressed. MIF showed an increased tendency in cases with advanced TNM stages, and at the same time, there was an inversely proportional relationship between MIF and LC3, Beclin1. The long-term survival of SACC patients is poor. MIF might be a risk factor for SACC patients, whereas, LC3 and Beclin1 might be an effective strategy for treatment of SACC.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adenoid cystic carcinoma
Observational Study
Malignancy
Gastroenterology
Salivary Glands
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Carcinoma
otorhinolaryngologic diseases
LC3
Humans
adenoid cystic carcinoma
030212 general & internal medicine
Risk factor
Beclin1
Pathology, Molecular
Survival rate
Macrophage Migration-Inhibitory Factors
Aged
Neoplasm Staging
Salivary gland
business.industry
MIF
General Medicine
Middle Aged
medicine.disease
Prognosis
Salivary Gland Neoplasms
Carcinoma, Adenoid Cystic
Salivary Gland Adenoid Cystic Carcinoma
Intramolecular Oxidoreductases
Survival Rate
stomatognathic diseases
medicine.anatomical_structure
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Immunohistochemistry
Beclin-1
Female
Mouth Neoplasms
business
Microtubule-Associated Proteins
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 98
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....4e4f6b99a71bb273ee831e88367883a5