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In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent
- Source :
- International Journal of Molecular Sciences; Volume 18; Issue 11; Pages: 2399, International Journal of Molecular Sciences, Vol 18, Iss 11, p 2399 (2017), International Journal of Molecular Sciences, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2017
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2017.
-
Abstract
- Silver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles. The nanoparticles were prepared in the hydrogel in situ, utilizing two variants of cashew gum as a capping agent, and sodium borohydride as the reducing agent. This gum is non-toxic and comes from a renewable natural source. The particles and gel were thoroughly characterized through using rheological measurements, UV-vis spectroscopy, nanoparticles tracking analysis, and transmission electron microscopy analysis (TEM). Antibacterial tests were carried out, confirming antimicrobial action of the silver nanoparticle-loaded gels. Furthermore, rat wound-healing models were used and demonstrated that the gels exhibited improved wound healing when compared to the base hydrogel as a control. Thus, these gels are proposed as excellent candidates for use as wound-healing treatments.
- Subjects :
- Male
Nanoparticle
Metal Nanoparticles
02 engineering and technology
01 natural sciences
Silver nanoparticle
Hydrogel, Polyethylene Glycol Dimethacrylate
lcsh:Chemistry
chemistry.chemical_compound
antibacterial activity
lcsh:QH301-705.5
Spectroscopy
General Medicine
021001 nanoscience & nanotechnology
healing
Computer Science Applications
Anti-Bacterial Agents
wounds
Transmission electron microscopy
Wounds
Pseudomonas aeruginosa
Silver nanoparticles
0210 nano-technology
Antibacterial activity
Rheology
medicine.drug
Staphylococcus aureus
silver nanoparticles
Silver
Healing
Reducing agent
Phthalic Acids
Microbial Sensitivity Tests
010402 general chemistry
Catalysis
Article
Inorganic Chemistry
Sodium borohydride
Polymer chemistry
medicine
Animals
Anacardium
Physical and Theoretical Chemistry
Particle Size
Rats, Wistar
Molecular Biology
Wound Healing
hydrogel
cashew gum
Organic Chemistry
Cashew gum
0104 chemical sciences
Carboxymethyl cellulose
Hydrogel
chemistry
Chemical engineering
lcsh:Biology (General)
lcsh:QD1-999
Carboxymethylcellulose Sodium
Particle size
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences; Volume 18; Issue 11; Pages: 2399
- Accession number :
- edsair.doi.dedup.....4e51927ffae9b82eff044fdd009ef631
- Full Text :
- https://doi.org/10.3390/ijms18112399