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In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent

Authors :
Cristina Delerue-Matos
Patrick Veras Quelemes
Alexandra Plácido
de Oliveira Rcm
de Almeida Mp
da Silva Da
Lustosa Akmf
de Almeida Leite Jrs
da Silva Fv
Oliveira Is
de Jesus Oliveira Ac
Amorim Adgn
Peter Eaton
Repositório Científico do Instituto Politécnico do Porto
Source :
International Journal of Molecular Sciences; Volume 18; Issue 11; Pages: 2399, International Journal of Molecular Sciences, Vol 18, Iss 11, p 2399 (2017), International Journal of Molecular Sciences, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
Publication Year :
2017
Publisher :
Multidisciplinary Digital Publishing Institute, 2017.

Abstract

Silver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles. The nanoparticles were prepared in the hydrogel in situ, utilizing two variants of cashew gum as a capping agent, and sodium borohydride as the reducing agent. This gum is non-toxic and comes from a renewable natural source. The particles and gel were thoroughly characterized through using rheological measurements, UV-vis spectroscopy, nanoparticles tracking analysis, and transmission electron microscopy analysis (TEM). Antibacterial tests were carried out, confirming antimicrobial action of the silver nanoparticle-loaded gels. Furthermore, rat wound-healing models were used and demonstrated that the gels exhibited improved wound healing when compared to the base hydrogel as a control. Thus, these gels are proposed as excellent candidates for use as wound-healing treatments.

Details

Language :
English
ISSN :
14220067
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences; Volume 18; Issue 11; Pages: 2399
Accession number :
edsair.doi.dedup.....4e51927ffae9b82eff044fdd009ef631
Full Text :
https://doi.org/10.3390/ijms18112399