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General Parity between Trio and Pairwise Breeding of Laboratory Mice in Static Caging
- Source :
- The Journal of Immunology. 193:4757-4760
- Publication Year :
- 2014
- Publisher :
- The American Association of Immunologists, 2014.
-
Abstract
- Changes made in the 8th edition of the Guide for the Care and Use of Laboratory Animals included new recommendations for the amount of space for breeding female mice. Adopting the new recommendations required, in essence, the elimination of trio breeding practices for all institutions. Both public opinion and published data did not readily support the new recommendations. In response, the National Jewish Health Institutional Animal Care and Use Committee established a program to directly compare the effects of breeding format on mouse pup survival and growth. Our study showed an overall parity between trio and pairwise breeding formats on the survival and growth of the litters, suggesting that the housing recommendations for breeding female mice as stated in the current Guide for the Care and Use of Laboratory Animals should be reconsidered.
- Subjects :
- Male
Gerontology
business.industry
Body Weight
Immunology
Institutional Animal Care and Use Committee
Autoimmunity
Guidelines as Topic
Mice, Transgenic
Breeding
Body weight
Housing, Animal
Article
Mice transgenic
Mice
Pup survival
Pregnancy
Animals
Immunology and Allergy
Medicine
Female
Pairwise comparison
Lymphocytes
business
Subjects
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 193
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....4e53ef1efaaa71f370a669405d4c3985