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Characterization and photodynamic activity of a new phthalocyanine nanoparticles
- Source :
- Journal of materials science. Materials in medicine. 23(7)
- Publication Year :
- 2012
-
Abstract
- Nanoparticles of a hydrophobic photosensitizer, tetrakis (3-trifluoromethylphenoxy) zinc phthalocyanine (FPcZn) have been synthesized by using a simple reprecipitation technique. The resulting drug nanoparticles (FPcZn-NP) were spherical, highly monodispersed and stable in aqueous system, without an additional stabilizer. Comparative studies with FPcZn-NP and FPcZn indicated that after the formation of nanoparticles, FPcZn-NP maintained the efficiency of (1)O(2) generation. Further more, the in vitro studies demonstrated that such nanoparticles can be efficiently taken up by Hela cells, which might be resulted to cell death by light irradiation. These properties could make the FPcZn-NP to be a promising candidate in clinical photodynamic therapy.
- Subjects :
- Materials science
Indoles
medicine.medical_treatment
Biomedical Engineering
Biophysics
Nanoparticle
Bioengineering
Photodynamic therapy
Isoindoles
Photochemistry
Biomaterials
HeLa
chemistry.chemical_compound
Dynamic light scattering
Microscopy, Electron, Transmission
medicine
Humans
Photosensitizer
Aqueous solution
Photosensitizing Agents
biology
Singlet Oxygen
biology.organism_classification
In vitro
chemistry
Photochemotherapy
Phthalocyanine
Nanoparticles
Spectrophotometry, Ultraviolet
HeLa Cells
Subjects
Details
- ISSN :
- 15734838
- Volume :
- 23
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of materials science. Materials in medicine
- Accession number :
- edsair.doi.dedup.....4ea308fd77457873788406082f82e4ec