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Structural insights into RbmA, a biofilm scaffolding protein of V. cholerae
- Source :
- PLoS ONE, PLoS ONE, Vol 8, Iss 12, p e82458 (2013)
- Publication Year :
- 2013
-
Abstract
- V. cholerae can form sessile biofilms associated with abiotic surfaces, cyanobacteria, zoo-plankton, mollusks, or crustaceans. Along with the vibrio polysaccharide, secreted proteins of the rbm gene cluster are key to the biofilm ultrastructure. Here we provide a thorough structural characterization of RbmA, a protein involved in mediating cell-cell and cell-biofilm contacts. We correlate our structural findings with initial ligand specificity screening results, NMR protein-ligand interaction analysis, and complement our results with a full biocomputational study.
- Subjects :
- Cyanobacteria
Scaffold protein
lcsh:Medicine
medicine.disease_cause
Ligands
Structure-Activity Relationship
Protein structure
Bacterial Proteins
Gene cluster
medicine
lcsh:Science
Nuclear Magnetic Resonance, Biomolecular
Vibrio cholerae
Multidisciplinary
biology
lcsh:R
fungi
Biofilm
biology.organism_classification
Vibrio
Protein Structure, Tertiary
Secretory protein
Biochemistry
Biofilms
lcsh:Q
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....4eb8372e42a84feb102a41be40ef9931