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Disease-Specific Survival of Type I and Type II Epithelial Ovarian Cancers—Stage Challenges Categorical Assignments of Indolence & Aggressiveness
- Source :
- Diagnostics, Vol 10, Iss 2, p 56 (2020), Diagnostics
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Epithelial ovarian cancers (EOC) consist of several sub-types based on histology, clinical, molecular and epidemiological features that are termed "histo-types", which can be categorized into less aggressive Type I and more aggressive Type II malignancies. This investigation evaluated the disease-specific survival (DSS) of women with Type I and II EOC using histo-type, grade, and stage. A total of 200,658 EOC cases were identified in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) data. Kaplan-Meier survival analyses, one-factor ANOVA and Chi-square analyses were performed on 10-year DSS survivals. DSS strongly supported a 2-tiered classification (grade 1 vs. grade 2 & 3) for serous EOC. DSS of early stage serous EOC for grade 2 was significantly different from grade 3 indicating that a 2-tier classification for serous EOC applied only to late stage. DSS of Type I EOC was much better than Type II. However, DSS was 46-58% lower with late stage Type I than with early stage Type I indicating that Type I ovarian cancers should not be considered indolent. Early stage Type II EOC had much better DSS than late stage Type II stressing that stage has a large role in survival of both Type I and II EOC.
- Subjects :
- Oncology
End results
epithelial ovarian cancer
medicine.medical_specialty
endocrine system diseases
Clinical Biochemistry
survival
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Epidemiology
medicine
Epithelial ovarian cancer
Stage (cooking)
grade
lcsh:R5-920
030219 obstetrics & reproductive medicine
business.industry
Disease specific survival
type ii
Late stage
Cancer
medicine.disease
type i &
histo-types
stage
female genital diseases and pregnancy complications
Type I & Type II
Serous fluid
030220 oncology & carcinogenesis
business
lcsh:Medicine (General)
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....4eca4382cbce5c71dc900953bea1d948