Back to Search
Start Over
Serum S100 calcium binding protein A4 improves the diagnostic accuracy of transient elastography for assessing liver fibrosis in hepatitis B
- Source :
- Clinics and research in hepatology and gastroenterology. 42(1)
- Publication Year :
- 2017
-
Abstract
- The diagnostic performance of Fibroscan might be improved when combined with other serum fibrosis related markers. Previous study has demonstrated that S100A4 expression is associated with liver fibrosis in humans with hepatitis. This study aimed to clarify diagnostic accuracy of serum S100A4 levels for significant liver fibrosis in patients with chronic hepatitis B (CHB), and develop a combined algorithm of liver stiffness measurement (LSM) and S100A4 to predict significant liver fibrosis in CHB.One hundred and seventy-five CHB patients who had performed liver biopsy were consecutively included. We evaluated serum S100A4 levels, LSM values and other clinically-approved fibrosis scores.Serum S100A4 level was higher in CHB patients with significant fibrosis, compared to those without [199.58 (33.31-1971.96) vs. 107.15 (2.10-1038.94), P0.001]. Using receiver-operating characteristic (ROC) analyses, the area under the curves (AUC), sensitivity, specificity and accuracy of S100A4 were found to be 0.749, 62.7%, 75.9% and 0.70 for significant fibrosis (≥Stage 2), respectively. Although not superior to LSM, these results were better than the fibrosis index based on the 4 factor (FIB-4) and the aspartate aminotransferase-to-platelet ratio index (APRI) for significant fibrosis detection. An algorithm consisting of S100A4 and LSM was derived. The AUC, sensitivity, specificity and accuracy of model based on serum S100A4 level and LSM were 0.866, 86.6%, 77.8% and 0.79 for significant fibrosis detection, superior to those based on LSM alone (0.834, 76.1%, 80.7% and 0.76, P=0.041).Serum S100A4 level was identified as a fibrosis marker of liver fibrosis in patients with CHB. Combining serum S100A4 with LSM improved the accuracy of transient elastography for hepatitis B significant fibrosis detection.
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Pathology
Liver fibrosis
Diagnostic accuracy
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Hepatitis B, Chronic
Fibrosis
Internal medicine
Biopsy
medicine
Humans
S100 Calcium-Binding Protein A4
Hepatitis
Hepatology
medicine.diagnostic_test
business.industry
Reproducibility of Results
Hepatitis B
medicine.disease
030220 oncology & carcinogenesis
Liver biopsy
Elasticity Imaging Techniques
030211 gastroenterology & hepatology
Female
business
Transient elastography
Algorithms
Subjects
Details
- ISSN :
- 2210741X
- Volume :
- 42
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinics and research in hepatology and gastroenterology
- Accession number :
- edsair.doi.dedup.....4ef190e2ac617c62e8f8ae7b5ff1b60e