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Conflicting effects of poly(ADP-ribose) polymerase inhibitor on cell-mediated and virion-mediated HTLV-1 infection
- Source :
- Virus research. 270
- Publication Year :
- 2018
-
Abstract
- Adult T-cell leukemia and human T-cell leukemia virus type 1 (HTLV-1) - associated myelopathy/tropical spastic paraparesis, which develop after HTLV-1 infection, are difficult to cure. In particular, the mode of HTLV-1 propagation is not well understood. Poly (ADP-ribose) polymerase-1 is reported to be a co-activator of HTLV-1 Tax protein; however, the effects of polyADP-ribosylation on infectivity of HTLV-1 have not been fully clarified. We studied the effects of a PARP inhibitor on two modes of HTLV-1 transmission: through cell adhesion between MT-2 cells (an HTLV-1-infected cell line) and uninfected cells and through virus particles produced by HTLV-1-producing c77 cells. Although the PARP inhibitor decreased HTLV-1 infection through cell adhesion, it increased HTLV-1 infection through virion production and caused apoptosis of HTLV-1-infected cells. Thus, careful consideration is required for clinical application of PARP inhibitors in HTLV-1 patients.
- Subjects :
- Cancer Research
Cell Survival
viruses
Poly ADP ribose polymerase
T-Lymphocytes
Virus Attachment
Apoptosis
Biology
Poly(ADP-ribose) Polymerase Inhibitors
Poly (ADP-Ribose) Polymerase Inhibitor
Cell Line
03 medical and health sciences
immune system diseases
hemic and lymphatic diseases
Virology
Tropical spastic paraparesis
medicine
Humans
Cell adhesion
030304 developmental biology
Cell Proliferation
0303 health sciences
Human T-lymphotropic virus 1
030306 microbiology
Virion
virus diseases
medicine.disease
Leukemia
Infectious Diseases
PARP inhibitor
HTLV-1 Infection
Subjects
Details
- ISSN :
- 18727492
- Volume :
- 270
- Database :
- OpenAIRE
- Journal :
- Virus research
- Accession number :
- edsair.doi.dedup.....4ef6341fd1ef2bf1e4c109110d401f13