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JAK2-STAT5B pathway and osteoblast differentiation
- Source :
- JAK-STAT
- Publication Year :
- 2013
-
Abstract
- Osteoblast differentiation is a critical step in the maintenance of bone homeostasis. Osteoblast differentiation is generally maintained by growth hormone (GH) and various other endocrine and autocrine/paracrine factors. JAK2-STAT5B pathway is a central axis in the mechanism of GH signaling. Similarly, the autocrine/paracrine signaling factor IGF-1 also mediates its effects through this pathway. Analysis on JAK2-STAT5B pathway showed its importance in the IGF-1/IGF-1R mediated regulation of gene expression and osteoblast differentiation. Persistent activation of STAT5B and inhibition of STAT5B degradation showed increased osteoblastic differentiation and STAT5B/Runx-2 activities. Conditional gene silencing studies showed the importance of the JAK2-STAT5B pathway in stimulation of other transcription factors and expression of various differentiation markers.
- Subjects :
- Regulation of gene expression
medicine.medical_specialty
animal structures
BMPs
STAT5B
food and beverages
Osteoblast
General Medicine
Growth hormone receptor
Review
Biology
Cell biology
Paracrine signalling
Endocrinology
medicine.anatomical_structure
growth hormone receptor
Internal medicine
osteoblast differentiation
medicine
Gene silencing
Autocrine signalling
Transcription factor
IGF-1R
hormones, hormone substitutes, and hormone antagonists
JAK2-STAT5B
Subjects
Details
- ISSN :
- 21623988
- Volume :
- 2
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- JAK-STAT
- Accession number :
- edsair.doi.dedup.....4f0f23b5ced933012b644000070aa615