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Supplementary Figure S6-S10 from Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition

Authors :
Yuchen Jiao
Xiaoyue Wang
Yi-Xin Zeng
Hai Yan
Wenjia Wang
Jiayu Wu
Qing Zhu
Yan Lu
Dingding Wang
Jianmei Liu
Song Liu
Bill H. Diplas
Hong Zhao
Junbo Liang
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Treatment of AZD1775 activated CDK pathway, which leads to S-phase arrest and DNA damage, and finally apoptosis of cells.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....4f1889dc314ad3be4b8e3814808569dc
Full Text :
https://doi.org/10.1158/0008-5472.22424655.v1