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Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants
- Source :
- Prostate Cancer, Vol 2015 (2015), Prostate Cancer
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Background. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer.Methods. In this study, thioredoxin 1 (Trx 1), an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project. A pathologist blindly scored levels of Trx 1. The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher’s exact test.Results. Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score (P=0.01) and inversely associated with dietary antioxidant intake (P=0.03). In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (P=0.01). No association was found for other erythrocyte enzymes. Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (P=0.04).Conclusion. These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants.
- Subjects :
- Cancer Research
medicine.medical_specialty
Pathology
animal structures
Antioxidant
Prostate biopsy
Article Subject
Urology
medicine.medical_treatment
Endogeny
lcsh:RC870-923
medicine.disease_cause
lcsh:RC254-282
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Prostate
Internal medicine
medicine
030304 developmental biology
0303 health sciences
medicine.diagnostic_test
biology
business.industry
Cancer
lcsh:Diseases of the genitourinary system. Urology
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Enzyme assay
3. Good health
Endocrinology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
biology.protein
business
Oxidative stress
Research Article
Subjects
Details
- ISSN :
- 2090312X and 20903111
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- Prostate Cancer
- Accession number :
- edsair.doi.dedup.....4f2023d43636e1f9e3eeaa2dd9824381