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Electroencephalographic Coherence in Alzheimer's Disease: Comparisons with a Control Group and Population Norms

Authors :
Vadim Ilivitsky
Verner Knott
Colleen Mahoney
Erich Mohr
Source :
Journal of Geriatric Psychiatry and Neurology. 13:1-8
Publication Year :
2000
Publisher :
SAGE Publications, 2000.

Abstract

Previous research from independent laboratories has shown reduced electroencephalographic coherence in patients diagnosed with dementia of the Alzheimer type (DAT). This study added to this work by comparing interhemispheric and intrahemispheric coherence in nonmedicated DAT patients (n = 35) with that of a normal control group (n = 30), as well as with a data bank of population norms. Raw and Z-score transformed values showed reduced coherence, interhemispherically (in delta, theta, alpha, and beta bands) and intrahemispherically (delta and theta bands) in DAT patients with both comparison procedures. Discriminant analysis correctly classified 73% to 75% of patients. The results are discussed in relation to earlier research, "trait" versus "state" factors, the cholinergic system, and cognitive processes in dementia. ( J Geriatr Psychiatry Neurol 2000; 13:1-8).

Details

ISSN :
15525708 and 08919887
Volume :
13
Database :
OpenAIRE
Journal :
Journal of Geriatric Psychiatry and Neurology
Accession number :
edsair.doi.dedup.....4f315971e1685574fb75390d83e8f0ce