Back to Search
Start Over
Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda
- Source :
- PLoS ONE, Vol 7, Iss 12, p e52571 (2012), PLoS ONE
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- Background: Antibodies are important in the control of blood stage Plasmodium falciparum infection. It is unclear which antibody responses are responsible for, or even associated with protection, partly due to confounding by heterogeneous exposure. Assessment of response to partially effective antimalarial therapy, which requires the host to assist in clearing parasites, offers an opportunity to measure protection independent of exposure. Methods: A cohort of children aged 1–10 years in Kampala, Uganda were treated with amodiaquine+sulfadoxinepyrimethamine for uncomplicated malaria. Serum samples from the time of malaria diagnosis and 14 days later were analyzed for total IgG to 8 P. falciparum antigens using a quantitative indirect ELISA. Associations between antibody levels and risk of treatment failure were estimated using Cox proportional hazard regression. Results: Higher levels of antibodies to apical membrane antigen 1 (AMA-1), but to none of the other 7 antigens were significantly associated with protection against treatment failure (HR 0.57 per 10-fold increase in antibody level, CI 0.41– 0.79, p=0.001). Protection increased consistently across the entire range of antibody levels. Conclusions: Measurement of antibody levels to AMA-1 at the time of malaria may offer a quantitative biomarker of blood stage immunity to P. falciparum, a tool which is currently lacking.
- Subjects :
- Epidemiology
Plasmodium falciparum
Immunoglobulins
Antibodies, Protozoan
lcsh:Medicine
Antigens, Protozoan
Amodiaquine
Global Health
Antimalarials
Species Specificity
Antigen
Immunity
parasitic diseases
Parasitic Diseases
medicine
Humans
Uganda
Malaria, Falciparum
Apical membrane antigen 1
Child
lcsh:Science
Immune Response
Multidisciplinary
biology
lcsh:R
Infant
biology.organism_classification
medicine.disease
Virology
Malaria
Biomarker Epidemiology
Infectious Diseases
Treatment Outcome
Child, Preschool
Humoral Immunity
Antibody Formation
Immunology
biology.protein
Medicine
Biomarker (medicine)
Clinical Immunology
lcsh:Q
Antibody
Research Article
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....4f54831d8a492983f6cdaa1b3bbedf35