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Sustained Inflation Versus Intermittent Positive Pressure Ventilation for Preterm Infants at Birth: Respiratory Function and Vital Sign Measurements
- Source :
- The Journal of Pediatrics, 239, 150-+. MOSBY-ELSEVIER, J Pediatr
- Publication Year :
- 2021
-
Abstract
- Objective To characterize respiratory function monitor (RFM) measurements of sustained inflations and intermittent positive pressure ventilation (IPPV) delivered noninvasively to infants in the Sustained Aeration of Infant Lungs (SAIL) trial and to compare vital sign measurements between treatment arms. Study design We analyzed RFM data from SAIL participants at 5 trial sites. We assessed tidal volumes, rates of airway obstruction, and mask leak among infants allocated to sustained inflations and IPPV, and we compared pulse rate and oxygen saturation measurements between treatment groups. Results Among 70 SAIL participants (36 sustained inflations, 34 IPPV) with RFM measurements, 40 (57%) were spontaneously breathing prior to the randomized intervention. The median expiratory tidal volume of sustained inflations administered was 5.3 mL/kg (IQR 1.1-9.2). Significant mask leak occurred in 15% and airway obstruction occurred during 17% of sustained inflations. Among 34 control infants, the median expiratory tidal volume of IPPV inflations was 4.3 mL/kg (IQR 1.3-6.6). Mask leak was present in 3%, and airway obstruction was present in 17% of IPPV inflations. There were no significant differences in pulse rate or oxygen saturation measurements between groups at any point during resuscitation. Conclusion Expiratory tidal volumes of sustained inflations and IPPV inflations administered in the SAIL trial were highly variable in both treatment arms. Vital sign values were similar between groups throughout resuscitation. Sustained inflation as operationalized in the SAIL trial was not superior to IPPV to promote lung aeration after birth in this study subgroup. Trial Registration Clinicaltrials.gov : NCT02139800 .
- Subjects :
- Male
Leak
Resuscitation
Gestational Age
Article
Intermittent Positive-Pressure Ventilation
medicine
Humans
Respiratory function
Respiratory system
Oxygen saturation (medicine)
Lung
Continuous Positive Airway Pressure
business.industry
Infant, Newborn
Airway obstruction
medicine.disease
Respiratory Function Tests
medicine.anatomical_structure
Infant, Extremely Premature
Anesthesia
Pediatrics, Perinatology and Child Health
Breathing
Female
business
Infant, Premature
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- The Journal of Pediatrics, 239, 150-+. MOSBY-ELSEVIER, J Pediatr
- Accession number :
- edsair.doi.dedup.....4f67b39ff7352cfbac556be34d80b3d2