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Testosterone is negatively associated with the severity of coronary atherosclerosis in men
- Source :
- Asian Journal of Andrology. 14:875-878
- Publication Year :
- 2012
- Publisher :
- Medknow, 2012.
-
Abstract
- This study aimed to determine whether plasma testosterone is associated with the severity of coronary atherosclerosis in a group of 803 men who underwent elective coronary angiography. Testosterone levels were measured in 803 male patients who were categorized into three groups according to testosterone level tertiles. All patients underwent elective coronary angiography, and the severity of coronary artery disease (CAD) was determined by the Gensini score. Moreover, patients were classified into two groups according to Gensini scores (score ≤26 and score >26) using the median values as cutoff points. The plasma testosterone levels were measured by an ELISA kit. The level of testosterone was negatively associated with the Gensini score (r=−0.188; P=0.000). A multiple linear regression analysis revealed that testosterone was an independent risk factor for the Gensini score (β=−0.110; P=0.002) after adjusting for confounding covariates. In a multivariate logistic regression model, the severity of CAD was shown to be significantly lower in the third tertile (highest) of testosterone compared to the first tertile (lowest) of testosterone (odds ratio (OR)=0.465; 95% confidence interval (CI): 0.327–0.662; P=0.000). In this study, patients with lower testosterone levels had higher Gensini scores in a group of 803 men who underwent elective coronary angiography. Additional studies are needed to clarify the direction of causality and possible underlying mechanisms.
- Subjects :
- Adult
Male
Risk
medicine.medical_specialty
Urology
Coronary Artery Disease
Coronary Angiography
Coronary artery disease
Negatively associated
Internal medicine
medicine
Humans
Testosterone
Risk factor
Coronary atherosclerosis
Aged
business.industry
Confounding
Testosterone (patch)
General Medicine
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Endocrinology
Linear Models
Cardiology
Regression Analysis
Original Article
business
Subjects
Details
- ISSN :
- 17457262 and 1008682X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Asian Journal of Andrology
- Accession number :
- edsair.doi.dedup.....4f98b2ff191216b3cb332e8a8c24375f