Back to Search
Start Over
High Apelin Level Indicates a Poor Prognostic Factor in Muscle-Invasive Bladder Cancer
- Source :
- Disease Markers, Disease Markers, Vol 2019 (2019)
- Publication Year :
- 2019
- Publisher :
- Hindawi Limited, 2019.
-
Abstract
- Purpose. To compare the expression level of apelin in muscle-invasive bladder cancer and matched paracarcinoma tissues and investigate the relationship between apelin and clinical prognosis in the patients. Methods. To assess apelin expression by using immunohistochemical method compared with bladder tumors and matched paracarcinoma tissues. Subsequently, the correlation of apelin expression with the clinicopathological features of bladder cancer patients was analyzed. Kaplan-Meier survival curves method was used to analyze apelin prognostic significance for muscle-invasive bladder cancer patients (including 404 muscle-invasive bladder cancer patients and 28 normal bladder tissues, in TCGA dataset). Results. Apelin protein level was overexpressed in bladder tumor tissues compared with paracarcinoma tissues. Furthermore, high apelin expression was associated with high tumor stage (P<0.05), distant metastasis (P<0.05), and vascular invasion (P<0.05). Kaplan-Meier curve analyses showed that the overexpression of apelin was a potential predictor of overall survival and disease-free survival. Conclusion. Apelin was upregulated in bladder tumor tissues compared with matched adjacent noncancer tissues, especially in the high tumor stage, distant metastasis, and vascular invasion. What is more, high expression of apelin in muscle-invasive bladder cancer indicates the poor prognosis. These data suggested that apelin might be a therapeutic potential biomarker in muscle-invasive bladder cancer patients.
- Subjects :
- Male
0301 basic medicine
Prognostic factor
Article Subject
Urinary Bladder
Clinical Biochemistry
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Tumor stage
Biomarkers, Tumor
Genetics
Humans
Medicine
Molecular Biology
Survival analysis
Aged
Muscle Neoplasms
lcsh:R5-920
Bladder cancer
business.industry
Carcinoma
Biochemistry (medical)
Muscle invasive
General Medicine
Middle Aged
Prognosis
medicine.disease
Up-Regulation
Apelin
030104 developmental biology
Urinary Bladder Neoplasms
030220 oncology & carcinogenesis
Cancer research
Immunohistochemistry
Female
Corrigendum
lcsh:Medicine (General)
business
Research Article
Subjects
Details
- ISSN :
- 18758630 and 02780240
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- Disease Markers
- Accession number :
- edsair.doi.dedup.....4fa9a9f723b4ee3815d5403e0cb6c1a8