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Current Concepts on the Reno-Protective Effects of Phosphodiesterase 5 Inhibitors in Acute Kidney Injury: Systematic Search and Review
- Source :
- Journal of Clinical Medicine, Vol 9, Iss 1284, p 1284 (2020), Journal of Clinical Medicine
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization, and mortality, especially in high risk patients. Phosphodiesterase 5 inhibitors (PDE5Is), currently available as first-line therapy of erectile dysfunction in humans, have shown a beneficial potential of reno-protection through various reno-protective mechanisms. The aim of this work is to provide a comprehensive overview of the available literature on the reno-protective properties of PDE5Is in the various forms of AKI. Medline was systematically searched from 1946 to November 2019 to detect all relevant animal and human studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. In total, 83 studies were included for qualitative synthesis. Sildenafil is the most widely investigated compound (42 studies), followed by tadalafil (20 studies), icariin (10 studies), vardenafil (7 studies), zaprinast (4 studies), and udenafil (2 studies). Even though data are limited, especially in humans with inconclusive or negative results of only two clinically relevant studies available at present, the results of animal studies are promising. The reno-protective action of PDE5Is was evident in the vast majority of studies, independently of the AKI type and the agent applied. PDE5Is appear to improve the renal functional/histopathological alternations of AKI through various mechanisms, mainly by affecting regional hemodynamics, cell expression, and mitochondrial response to oxidative stress and inflammation.
- Subjects :
- Sildenafil
icariin
030232 urology & nephrology
lcsh:Medicine
Review
Avanafil
sildenafil citrate
Bioinformatics
renal insufficiency
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
zaprinast
udenafil
avanafil
Medicine
Udenafil
business.industry
lcsh:R
Acute kidney injury
phosphodiesterase 5 inhibitors
General Medicine
vardenafil dihydrochloride
medicine.disease
Systematic review
chemistry
acute kidney injury
Vardenafil
030220 oncology & carcinogenesis
cGMP-specific phosphodiesterase type 5
Animal studies
business
tadalafil
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 9
- Issue :
- 1284
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....4fb4176088f95cc3a05fe7272bd15445