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Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents

Authors :
Carlos F. G. C. Geraldes
S. W. Annie Bligh
Miao Jin
Gareth R. Williams
Dominic E.M. Spillane
Source :
Dalton transactions (Cambridge, England : 2003). 44(47)
Publication Year :
2015

Abstract

The ion exchange intercalation of two Gd-based magnetic resonance imaging contrast agents into hydroxy double salts (HDSs) is reported. The presence of Gd(3+) diethylenetriaminepentaacetate and Gd(3+) diethylenetriaminepenta(methylenephosphonate) complexes in the HDS lattice after intercalation was confirmed by microwave plasma-atomic emission spectroscopy. The structural aspects of the HDS-Gd composites were studied by X-ray diffraction, with the intercalates having an interlayer spacing of 14.5-18.6 Å. Infrared spectroscopy confirmed the presence of characteristic vibration peaks associated with the Gd(3+) complexes in the intercalation compounds. The proton relaxivities of the Gd(3+) complex-loaded composites were 2 to 5-fold higher in longitudinal relaxivity, and up to 10-fold higher in transverse relaxivity, compared to solutions of the pure complexes. These data demonstrate that the new composites reported here are potentially potent MRI contrast agents.

Details

ISSN :
14779234
Volume :
44
Issue :
47
Database :
OpenAIRE
Journal :
Dalton transactions (Cambridge, England : 2003)
Accession number :
edsair.doi.dedup.....4fb81f78f79108758f8b2d23f289d86f