Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor

Authors :: Ann M. Decker
Md Toufiqur Rahman
Chad M. Kormos
David Hesk
Emmanuel Darcq
Brigitte L. Kieffer
Chunyang Jin
Source :: Bioorganicmedicinal chemistry letters. 80
Publication Year :: 2022
Abstract: GPR88 is an orphan G protein-coupled receptor which has been implicated in a number of striatal-associated disorders. Herein we describe the synthesis and pharmacological characterization of the first GPR88 radioligand, [

Subjects :: Organic Chemistry
Clinical Biochemistry
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Molecular Biology
Biochemistry

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