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Sedentary work and the risks of colon and rectal cancer by anatomical sub-site in the Canadian census health and environment cohort (CanCHEC)
- Source :
- Cancer epidemiology. 49
- Publication Year :
- 2017
-
Abstract
- Background Sedentary behaviour is a potential risk factor for colorectal cancer. We examined the association between sedentary work, based on body position, and colorectal cancer risk in Canadians. Methods A working body position category (a. sitting; b. standing and walking; c. sitting, standing, and walking; d. other) was assigned to occupations reported by 1991 Canadian Census respondents based on national occupational counselling guidelines. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated for cancers of the colon (overall, proximal, and distal) and rectum in men and women newly diagnosed from 1992 to 2010. Results Compared to “sitting” jobs, men in occupations with “other” (non-sitting, −standing, or −walking) body positions had a weakly significant reduced colon cancer risk (HR = 0.93, 95% CI: 0.89, 0.98) primarily attributed to protection at the distal site (HR = 0.90, 95% CI: 0.84, 0.97). Men in “standing and walking” and “sitting, standing, and walking” jobs did not have significantly reduced colon cancer risks. No effects were observed for rectal cancer in men or colon and rectal cancer in women. Conclusion The two significant findings of this analysis should be followed-up in further investigations with additional information on potential confounders. Null findings for rectal cancer were consistent with other studies.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Canada
Epidemiology
Colorectal cancer
Rectum
Environment
Sitting
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Risk Factors
Medicine
Humans
030212 general & internal medicine
Occupations
Sedentary lifestyle
Proportional Hazards Models
business.industry
Rectal Neoplasms
Hazard ratio
Confounding
Censuses
Middle Aged
medicine.disease
Confidence interval
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Cohort
Colonic Neoplasms
Physical therapy
Female
Sedentary Behavior
business
Demography
Subjects
Details
- ISSN :
- 1877783X
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Cancer epidemiology
- Accession number :
- edsair.doi.dedup.....4fe4035ca74dc385b58c30266634b898