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Type 2 diabetes and hepatocellular carcinoma: A case-control study in patients with chronic hepatitis B
- Source :
- International Journal of Cancer. 131:1197-1202
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Type 2 diabetes has been suggested as an independent risk factor for the development of hepatocellular carcinoma (HCC). However, the role of Type 2 diabetes on the development of HCC in the presence of chronic hepatitis B (CHB) remains inconclusive. We conducted this hospital-based case-control study to evaluate the roles of Type 2 diabetes in HCC development in patients with CHB. From January 2004 to December 2008, a total of 6,275 eligible consecutive patients with chronic hepatitis B virus (HBV) infection were recruited. A total of 1,105 of them were patients with HBV-related HCC and 5,170 patients were CHB but without HCC. We used multivariate logistic regression models to investigate the association between Type 2 diabetes and HCC risk. The prevalence of Type 2 diabetes is higher among HCC patients without cirrhosis than among those with cirrhosis (12.1% vs. 6.7%, p=0.003). Type 2 diabetes was associated with a significantly high risk of HCC in female patients after adjusting for age, family history of HCC, city of residence, hepatitis B e antigen and cirrhosis with an odds ratio (95% confidence interval, CI) of 1.9 (1.1-3.4). Restricted analyses among female patients without cirrhosis indicated that Type 2 diabetes was strongly associated with HCC risk with adjusted odds ratio (95% CI) of 5.6 (2.2-14.1). In conclusion, Type 2 diabetes is independently associated with the increased risk of HCC in female CHB patients. Female CHB patients with Type 2 diabetes are of a high HCC risk population and should be considered for HCC close surveillance program.
- Subjects :
- Adult
Male
China
Hepatitis B virus
Cancer Research
medicine.medical_specialty
Carcinoma, Hepatocellular
Population
Type 2 diabetes
Gastroenterology
Diabetes Complications
Hepatitis B, Chronic
Risk Factors
Diabetes mellitus
Internal medicine
Prevalence
medicine
Humans
Hepatitis B e Antigens
Prospective Studies
Risk factor
education
neoplasms
Neoplasm Staging
education.field_of_study
business.industry
Liver Neoplasms
Case-control study
Odds ratio
Middle Aged
Hepatitis B
Prognosis
medicine.disease
digestive system diseases
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Oncology
Case-Control Studies
Hepatocellular carcinoma
Female
business
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi.dedup.....4fe9a5000eb9d1bc8344c265405f028e