MITOCHONDRIAL NA+/CA2+ EXCHANGER INHIBITION DURING REPERFUSION EXHIBITS POTENTIAL CARDIOPROTECTIVE EFFECT, IN A PORCINE ISCHEMIA-REPERFUSION MODEL

Authors :: John Terrovitis
Lampros Katsaros
Apostolos Papalois
Vasilios Sousonis
Stefania Sventzouri
Argyrios Ntalianis
Nickolaos Michelinakis
Chris J. Kapelios
Titika Sfakianaki
John N. Nanas
Source :: Journal of the American College of Cardiology. (10):E27
Publisher :: American College of Cardiology Foundation. Published by Elsevier Inc.
Abstract: Inhibition of mitochondrial Na+/Ca2+ exchanger has been recently recognized as a novel therapeutic target for the prevention of arrhythmias in heart failure. We examined the effects of CGP-37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, administered at the onset of reperfusion, on

Subjects :: business.industry
Heart failure
Ischemia
medicine
Pharmacology
Cardiology and Cardiovascular Medicine
medicine.disease
business

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