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The protective effects of chronic intermittent hypobaric hypoxia pretreatment against collagen-induced arthritis in rats
- Source :
- Journal of Inflammation (London, England)
- Publication Year :
- 2015
- Publisher :
- BioMed Central, 2015.
-
Abstract
- Objective To explore the immunological mechanisms underlying the effect of chronic intermittent hypobaric hypoxia (CIHH) pretreatment on collagen-induced arthritis (CIA) in rat. Methods Fifty-four adult male Sprague–Dawley rats were used in the experiment. Arthritis in CIA rats (n=18) was induced by injection of collagen. The CIHH+CIA rats (n=18) were treated with CIHH (simulated 3000 m altitude, 5 hours per day for 28 days, PO2=108.8 mmHg) before CIA. The control rats (n=18) were not given any treatment. Results (1) Incidence rate of CIA in CIHH+CIA rats was significantly lower than that in CIA rats (P
- Subjects :
- musculoskeletal diseases
Allergy
medicine.medical_specialty
animal structures
Clinical Biochemistry
T lymphocytes
Arthritis
HIF-1α
macromolecular substances
Pharmacology
NF-κB
chemistry.chemical_compound
Internal medicine
medicine
Rheumatoid arthritis
skin and connective tissue diseases
Th1/Th2
business.industry
Research
Cell Biology
medicine.disease
musculoskeletal system
Molecular medicine
Rheumatology
chemistry
Immunology
Rat
Hypobaric hypoxia
business
Chronic intermittent hypobaric hypoxia
Collagen-induced arthritis
Subjects
Details
- Language :
- English
- ISSN :
- 14769255
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Inflammation (London, England)
- Accession number :
- edsair.doi.dedup.....4ff3a94dd578cba81deedbb8bf406e39