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Atlas registration for edema-corrected MRI lesion volume in mouse stroke models
- Source :
- Journal of cerebral blood flow & metabolism 39(2), 313-323 (2017). doi:10.1177/0271678X17726635, Journal of Cerebral Blood Flow & Metabolism
- Publication Year :
- 2019
- Publisher :
- Sage, 2019.
-
Abstract
- Lesion volume measurements with magnetic resonance imaging are widely used to assess outcome in rodent models of stroke. In this study, we improved a mathematical framework to correct lesion size for edema which is based on manual delineation of the lesion and hemispheres. Furthermore, a novel MATLAB toolbox to register mouse brain MR images to the Allen brain atlas is presented. Its capability to calculate edema-corrected lesion size was compared to the manual approach. Automated image registration performed equally well in in a mouse middle cerebral artery occlusion model (Pearson r = 0.976, p = 2.265e-11). Information encapsulated in the registration was used to generate maps of edema induced tissue volume changes. These showed discrepancies to simplified tissue models underlying the manual approach. The presented techniques provide biologically more meaningful, voxel-wise biomarkers of vasogenic edema after stroke.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
neuroanatomy
Image registration
diagnostic imaging [Brain Edema]
Lesion
03 medical and health sciences
Mice
0302 clinical medicine
Atlas (anatomy)
etiology [Brain Edema]
Edema
diagnostic imaging [Stroke]
Medicine
Animals
complications [Stroke]
ddc:610
Stroke
brain edema
medicine.diagnostic_test
business.industry
diagnostic imaging [Blood-Brain Barrier]
Brain atlas
Magnetic resonance imaging
Original Articles
medicine.disease
Magnetic Resonance Imaging
animal models
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Neurology
Blood-Brain Barrier
Neurology (clinical)
Radiology
medicine.symptom
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Neuroanatomy
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of cerebral blood flow & metabolism 39(2), 313-323 (2017). doi:10.1177/0271678X17726635, Journal of Cerebral Blood Flow & Metabolism
- Accession number :
- edsair.doi.dedup.....4ff864c3dabce2a137a5312729f72baf