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Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
- Source :
- Molecules, Molecules, Vol 26, Iss 7065, p 7065 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Cynanchum auriculatum Royle ex Wight. (CA), Cynanchum bungei Decne. (CB) and Cynanchum wilfordii (Maxim.) Hemsl. (CW) are three close species belonging to the Asclepiadaceous family, and their dry roots as the bioactive part have been revealed to exhibit anti-tumor, neuroprotection, organ protection, reducing liver lipid and blood lipid, immunomodulatory, anti-inflammatory, and other activities. Until 2021, phytochemistry investigations have uncovered 232 compounds isolated from three species, which could be classified into C21-steroids, acetophenones, terpenoids, and alkaloids. In this review, the morphology characteristics, species identification, and the relationship of botany, extraction, and the separation of chemical constituents, along with the molecular mechanism and pharmacokinetics of bioactive constituents of three species, are summarized for the first time, and their phytochemistry, pharmacology, and clinical safety are also updated. Moreover, the direction and limitation of current research on three species is also discussed.
- Subjects :
- Phytochemistry
Pharmaceutical Science
Organic chemistry
Review
Analytical Chemistry
Cynanchum wilfordii (Maxim.) Hemsl
QD241-441
Drug Discovery
Species identification
caudatin
Physical and Theoretical Chemistry
Cynanchum auriculatum Royle ex Wight
cynandione A
Cynanchum auriculatum
biology
Traditional medicine
Cynanchum bungei Decne
Cynanchum bungei
biology.organism_classification
Terpenoid
Chemistry (miscellaneous)
Cynanchum wilfordii
Molecular mechanism
Molecular Medicine
Clinical safety
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....4ff9067ae25b848019c0f65796acb7b9