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Integrity of the uncinate fasciculus is associated with the onset of bipolar disorder: a 6-year followed-up study
- Source :
- Translational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021), Translational Psychiatry
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group, 2021.
-
Abstract
- Patients with Bipolar Disorder (BD) are associated with aberrant uncinate fasciculus (UF) that connects amygdala-ventral prefrontal cortex (vPFC) system, but the casual relationship is still uncertain. The research aimed to investigate the integrity of UF among offspring of patients with BD and investigate its potential causal association with subsequent declaration of BD. The fractional anisotropy (FA) and mean diffusivity (MD) of UF were compared in asymptomatic offspring (AO, n = 46) and symptomatic offspring (SO, n = 45) with a parent with BD, and age-matched healthy controls (HCs, n = 35). Logistic regressions were performed to assess the predictive effect of UF integrity on the onset of BD. The three groups did not differ at baseline in terms of FA and MD of the UF. Nine out of 45 SO developed BD over a follow-up period of 6 years, and the right UF FA predicted the onset of BD (p = 0.038, OR = 0.212, 95% CI = 0.049–0.917). The ROC curve revealed that the right UF FA predicted BD onset (area-under-curve = 0.859) with sensitivity of 88.9% and specificity of 77.3%. The complementary whole-brain tract-based spatial statistics (TBSS) showed that widespread increases of FA were found in the SO group compared with HCs, but were not associated with the onset of BD. Our data provide evidence supporting the causal relationship between the white matter structural integrity of the amygdala-vPFC system and the onset of BD in genetically at-risk offspring of BD patients.
- Subjects :
- medicine.medical_specialty
Bipolar Disorder
Uncinate Fasciculus
Offspring
Uncinate fasciculus
Predictive markers
Asymptomatic
Gastroenterology
Article
lcsh:RC321-571
White matter
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Internal medicine
Fractional anisotropy
medicine
Humans
Bipolar disorder
Prefrontal cortex
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Biological Psychiatry
business.industry
Structural integrity
medicine.disease
White Matter
030227 psychiatry
Psychiatry and Mental health
Diffusion Tensor Imaging
medicine.anatomical_structure
Anisotropy
Nerve Net
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 21583188
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Translational Psychiatry
- Accession number :
- edsair.doi.dedup.....501434167cb31a0506a9d44916082cdf