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Vertebral Fracture Diagnosis in the Multinational BONE Study of Oral Ibandronate: Quality Management in Radiology
- Source :
- Journal of Clinical Densitometry. 11:221-231
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- A multicenter trial has established the antifracture efficacy of oral daily (2.5mg) as well as intermittent (20mg every other day for 12 doses every 3mo) ibandronate in women with postmenopausal osteoporosis. As diagnostic spinal radiographs for this trial were read at 2 centers, the study protocol included rigorous procedures for diagnosis of morphometric vertebral fractures. These included standardized qualitative and morphometric assessment methods for diagnosing vertebral osteoporotic fractures and consensus cross-validation procedures for maximizing fracture diagnostic accuracy and consistency between the 2 radiographic reading centers. Using these stringent measures, the between-center discrepancy in the diagnosis of prevalent fractures was only 8%. Furthermore, after cross-validation, discrepancy in the final diagnosis of incident fractures between centers was found for only 4 patients, resulting in a net gain of only 2 fractures in the trial. This meticulous methodology provided a highly effective means of identifying vertebral fractures and recruiting the trial population in which to assess the efficacy of ibandronate in postmenopausal osteoporosis.
- Subjects :
- medicine.medical_specialty
Every other day
Quality management
Endocrinology, Diabetes and Metabolism
Radiography
Population
Diagnostic accuracy
Postmenopausal osteoporosis
Bone Density
Multicenter trial
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Orthopedics and Sports Medicine
education
Ibandronic Acid
Osteoporosis, Postmenopausal
education.field_of_study
Bone Density Conservation Agents
Diphosphonates
business.industry
Middle Aged
Assessment methods
Spinal Fractures
Female
Radiology
business
Subjects
Details
- ISSN :
- 10946950
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Densitometry
- Accession number :
- edsair.doi.dedup.....501e4bc2b737c4163c836012adc67d02