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Pulmonary hypertension in systemic lupus erythematosus
- Source :
- Rheumatology international. 18(4)
- Publication Year :
- 1999
-
Abstract
- A prospective echocardiographic and clinical study was performed on 84 Chinese patients with systemic lupus erythematosus (SLE) and 99 controls to investigate the prevalence and the mechanism of pulmonary hypertension (PH) in SLE. Comparison between Doppler estimation and catheterization measurement was made in 12 cases to validate the predictive method. Compared to normal subjects, lupus patients had significantly increased systolic pulmonary artery pressure (SPAP) (29.59 +/- 12.52 vs 19.64 +/- 5.82, P0.001), mean pulmonary artery pressure (MPAP) (15.11 +/- 7.36 vs 10.21 +/- 4.72, P0.001) and total pulmonary resistance (TPR) (315.85 +/- 190.65 vs 220.37 +/- 55.92, P0.001). Nine of the 84 patients presented PH, defined as SPAP30 mmHg and MPAP20 mmHg. Pulmonary hypertensive patients had higher serum endothelin (ET) than non-pulmonary hypertensive patients, were more commonly in active stages, and presented Raynaud's phenomenon and rheumatoid factors. ET level was correlated with echocardiographic pulmonary pressure. Pulmonary hypertension commonly occurs in Chinese patients with SLE (11%), and it correlates with the lupus activity and the elevation of serum endothelin.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Cardiac Catheterization
China
Adolescent
medicine.medical_treatment
Hypertension, Pulmonary
Immunology
Rheumatology
immune system diseases
Reference Values
Internal medicine
medicine.artery
medicine
Prevalence
Immunology and Allergy
Humans
Lupus Erythematosus, Systemic
Prospective Studies
skin and connective tissue diseases
Cardiac catheterization
Aged
Systemic lupus erythematosus
Lupus erythematosus
business.industry
Endothelins
Respiratory disease
Middle Aged
medicine.disease
Pulmonary hypertension
Echocardiography, Doppler
Pulmonary artery
Cardiology
Linear Models
Female
Endothelin receptor
business
Subjects
Details
- ISSN :
- 01728172
- Volume :
- 18
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Rheumatology international
- Accession number :
- edsair.doi.dedup.....5035b7eae3965a9c0031c37f98bfed6a