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Indium Mediated Allylation of N-tert-Butanesulfinyl Imines with 1,3-Dibromopropene: Stereoselective Synthesis of Aziridines
- Source :
- RUA. Repositorio Institucional de la Universidad de Alicante, Universidad de Alicante (UA)
- Publication Year :
- 2018
- Publisher :
- The Japan Institute of Heterocyclic Chemistry, 2018.
-
Abstract
- The reaction of N-tert-butanesulfinyl imines 1 with 1,3-dibromopropene (2), in the presence of indium metal, in saturated aqueous solution of sodium bromide, produced bromohomoallylamine derivatives 3 with total facial diastereoselectivity for the imine addition, and moderate yields. These compounds were easily transformed into the corresponding vinyl aziridines 5 upon deprotonation with KHMDS in THF, the intramolecular cyclization taking place in a stereospecific manner in moderate to high yields. We thank the continued financial support from our Ministerio de Economía y Competitividad (MINECO; project CTQ2014-53695-P, CTQ2014-51912-REDC, CTQ2016-81797-REDC, CTQ2017-85093-P), FEDER, the Generalitat Valenciana (PROMETEOII/2014/017), and the University of Alicante.
- Subjects :
- Pharmacology
Allylation
010405 organic chemistry
Chemistry
Indium mediated
Organic Chemistry
Aziridines
N-tert-butanesulfinyl imines
010402 general chemistry
01 natural sciences
Medicinal chemistry
0104 chemical sciences
Analytical Chemistry
Stereoselective
Synthesis
Química Orgánica
Indium-mediated allylation
Stereoselectivity
1,3-dibromopropene
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- RUA. Repositorio Institucional de la Universidad de Alicante, Universidad de Alicante (UA)
- Accession number :
- edsair.doi.dedup.....50398005ac5bec815b28737168e65196