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EDEn–Electroceutical Design Environment: Ion Channel Tissue Expression Database with Small Molecule Modulators
- Source :
- iScience, Vol 11, Iss, Pp 42-56 (2019), iScience
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Summary The emerging field of bioelectricity has revealed numerous new roles for ion channels beyond the nervous system, which can be exploited for applications in regenerative medicine. Developing such biomedical interventions for birth defects, cancer, traumatic injury, and bioengineering first requires knowledge of ion channel targets expressed in tissues of interest. This information can then be used to select combinations of small molecule inhibitors and/or activators that manipulate the bioelectric state. Here, we provide an overview of electroceutical design environment (EDEn), the first bioinformatic platform that facilitates the design of such therapeutic strategies. This database includes information on ion channels and ion pumps, linked to known chemical modulators and their properties. The database also provides information about the expression levels of the ion channels in over 100 tissue types. The graphical interface allows the user to readily identify chemical entities that can alter the electrical properties of target cells and tissues.<br />Graphical Abstract<br />Highlights • Design of electroceuticals requires knowledge of ion channel targets and relevant drugs • EDEn allows rapid determination of which ion channels are expressed in a given tissue • EDEn also reveals what channel openers and blockers exist for any of the targets • This platform is a key enabling step for the design of bioelectric interventions<br />Bioinformatics; Biological Database
- Subjects :
- 0301 basic medicine
Multidisciplinary
Biomedical intervention
Database
Computer science
Bioinformatics
Biological database
Biological Database
02 engineering and technology
021001 nanoscience & nanotechnology
computer.software_genre
Regenerative medicine
Small molecule
Article
3. Good health
03 medical and health sciences
030104 developmental biology
Tissue expression
lcsh:Q
0210 nano-technology
lcsh:Science
computer
Ion channel
Subjects
Details
- Language :
- English
- ISSN :
- 25890042
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- iScience
- Accession number :
- edsair.doi.dedup.....5041f44adf159f0d49928b2c312923df