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Genetics of IL6 polymorphisms: Case–control study of the risk of endometrial cancer
- Source :
- Molecular Genetics & Genomic Medicine
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- Background Endometrial cancer is the most common gynaecological malignancy. Cytokines gene may be important in endometrial cancer development. This study sought to investigate whether the IL4, IL6 two gene genetic variants were associated with susceptibility to endometrial cancer (EC) in Hainan Chinese Han women by a hospital‐based study. Methods The genetic polymorphisms for IL4 and IL6 were analyzed by Agena MassARRAY method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression. Results We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09–2.37, p = 1.55 × 10−2), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11–4.53, p = 3.13 × 10−9). However, for IL4 gene, no associations emerged the SNP and EC risk. Conclusion This study demonstrated that IL6 gene polymorphisms are significantly associated with increased EC susceptibility in Hainan Chinese Han women.
- Subjects :
- 0301 basic medicine
Oncology
Adult
medicine.medical_specialty
China
Case–control study
030105 genetics & heredity
Logistic regression
Polymorphism, Single Nucleotide
03 medical and health sciences
genetic polymorphisms
Internal medicine
Genetics
medicine
SNP
Humans
Interleukin 6
Molecular Biology
Gene
Genetics (clinical)
Aged
biology
business.industry
Interleukin-6
Endometrial cancer
Case-control study
Odds ratio
Original Articles
Middle Aged
medicine.disease
Confidence interval
IL6
Endometrial Neoplasms
030104 developmental biology
endometrial cancer
biology.protein
Original Article
Female
Interleukin-4
business
Subjects
Details
- Language :
- English
- ISSN :
- 23249269
- Volume :
- 7
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Molecular Genetics & Genomic Medicine
- Accession number :
- edsair.doi.dedup.....5051d036b9c9a3e4b2d8e58b38eb18b2